基于糖烯自由基串联反应的氨基糖碳苷合成研究

碳糖苷作为氧糖苷稳定的类似物，在药物创制和小分子探针发展中有着重要的应用前景，然而其合成方法的发展却远远滞后于相应的氧糖苷类似物，因此发展高效的碳苷合成方法对于开展相关研究尤为重要。本课题计划以糖烯底物为原料，发展系列光介导糖基自由基参与的串联反应，实现对碳糖苷绿色、高效、高立体选择性合成。该项目的实施将为已有方法难于合成的氨基糖碳苷提供新合成途径。

As stable analogues of O-glycosides, C-glycosides hold great potential in the development of new drugs and biological probes. However, the development of C-glycosylation lags far behind the corresponding O-glycosylation. Therefore, it is highly desirable to develop efficient methods for C-glycosides. This project plans to develop a series of photo-mediated cascade reactions involving glycosyl radicals for the green, efficient and stereoselective synthesis of C-glycosides from glycals. The implementation of this project will provide tools for the synthesis of novel 2-amino-2-deoxy C-glycosides, which are difficult to obtain using existing methods.