UiO-66型同手性MOF膜的构筑及其手性分离机制的研究

针对目前手性分离膜的选择性与通量不可兼得，且缺乏对于手性化合物在膜中分离机制的研究，项目提出构筑具有高效手性分离性能的同手性金属有机框架（h-MOF）分离膜并阐释手性化合物在其中的传递与分离机制。本项目拟通过将手性功能基团引入至高稳定性的UiO-66型MOF框架中，合成对分离目标物具有亲和性的h-MOF膜，利用其规整的孔结构以及易调控的化学性质，实现手性化合物的高效分离。通过对制膜参数的优化，研究各项参数对h-MOF构筑的影响规律；通过后改性修饰精确调控h-MOF的壁面化学性质，研究其通道的构型特征以及其化学性质对于手性分离性能的影响；通过考察手性化合物在膜通道中的传递与分离特性并结合计算模拟的结果，揭示手性化合物的传递与分离机制。研究成果将为h-MOF分离膜的制备与发展提供新的策略，为手性分离机制研究奠定理论基础。

In order to overcome the trade-off effect of flux and selectivity of chiral separation membranes and make up the lack of research on the separation mechanism of chiral compounds in membranes, herein, this project proposed to construct homochiral metal-organic framework (h-MOF) membranes with high-efficient chiral separation performance and explain the transfer and separation mechanism of chiral compounds. By introducing versatile chiral functional sites into the UiO-66 type MOF framework to fabricate h-MOF membranes with affinity for the targeted chiral molecule, due to their regular pore structure and easy-to-control chemical properties. The project aims to construct UiO-66 h-MOF membranes at room temperature by optimizing the fabrication parameters and precisely controlling the channel chemical properties. The structural and morphological features of h-MOF membranes will be well characterized. The influence of the chemical properties of h-MOF on chiral separation and the transport behavior of chiral compounds in h-MOF membranes will be investigated. We will propose the transport mechanism of chiral compounds in h-MOF membranes. The research findings will help to provide new strategies for the development of h-MOF membranes and lay a theoretical foundation for mechanisms of chiral separation.