鳖龙软肝汤抑制生孢梭菌介导的色氨酸代谢改善HBV相关性肝癌免疫抑制的机制研究

肝癌的发生发展与机体代谢紊乱密切相关，而乙肝病毒慢性感染所致的HBV相关性肝癌患者体内的代谢与免疫紊乱状况更为复杂，近年来，肠道菌群失调、肠道微生态代谢失衡被认为在肿瘤发展过程中发挥了重要作用，但其导致HBV相关性肝癌发生发展的机制尚不清楚。课题组前期研究表明鳖龙软肝汤可改善患者免疫紊乱状况，且可显著下调患者肠道菌群中负责色氨酸分解的生孢梭菌，而色氨酸的代谢产物与肿瘤的发展密切相关；因此，本项目拟进一步探讨和证实：鳖龙软肝汤通过改善肠道微生态进而调控HBV相关性肝癌进展的可能途径和具体机制，为临床中医药改善HBV相关性肝癌患者的预后提供指导思路以及为中医药防治肝癌提供微观基础和理论支持。

The occurrence and development of hepatocellular carcinoma are closely related to the metabolic disorders of the body. The metabolic and immune disorders in patients with HBV-related liver cancer caused by chronic hepatitis B virus infection are more complicated. In recent years, the imbalance of intestinal flora and intestinal microecological metabolism are considered to play an important role in the development of tumors, but the mechanism that leads to the occurrence and development of HBV-related liver cancer is still unclear. The previous research of the research group showed that Bielong Ruangan Decoction can improve the immune disorders of patients, and can significantly down-regulate the intestinal flora of patients with Clostridium sporogenes responsible for the decomposition of tryptophan, and the metabolites of tryptophan are closely related to the development of tumors. Therefore, this project intends to further explore and confirm: Bielong Ruangan Decoction regulates the possible pathways and specific mechanisms of HBV-related liver cancer progression by improving the intestinal microecology, and provides guidance for clinical Chinese medicine to improve the immune function of HBV-related liver cancer patients And Chinese medicine provides micro-foundation and theoretical support for the prevention and treatment of liver cancer.