基于直接重建11C-acetate动力学参数图像的心肌外部效率测量方法

心肌外部效率（Myocardial External Efficiency, MEE）是临床进行心肌病病情评估和预后预测的重要定量指标。目前，多采用11碳-乙酸盐（11C-acetate）PET成像测量MEE。在采用11C-acetate PET测量MEE时，需先重建动态图像，再逐像素计算得到动力学参数，最后结合左心室功能参数计算得到MEE。然而，PET图像固有的噪声会导致参数图像质量差。此外，左心室功能参数需借助其他影像学检查获得，增加了扫描的复杂度，提高了患者的检查成本。本研究针对以上问题，开展如下研究：1）从投影数据中直接重建出动力学参数图像，提高参数图像成像质量；2）通过动力学参数图像测量左心室功能参数，无需其他影像学检查辅助；3）对重建的图像和计算的左心室功能参数进行分析与评价，进一步优化算法中的参数，为临床通过单次PET扫描测量MEE提供研究基础。

Myocardial external efficiency (MEE) is an important quantitative marker in evaluation and prognosis of cardiomyopathy. Now, 11C-acetate PET has been widely used in measuring MEE. The measurement of MEE using 11C-acetated includes reconstruction of dynamic images, fitting of kinetic parameters, and calculation of MEE with left ventricular parameters. However, the noise on PET images led to a poor quality of images of kinetic parameters. In addition, the measurement of left ventricle parameters by other imaging techniques increased the complexity and cost of the examination. Consequently, this research focused on the following issues: 1) The images of kinetic parameters were directly reconstructed from projection data to improve the image quality; 2) Left ventricular parameters were measured by the images of kinetic parameters, without the need for the additional imaging modality; 3) The analysis and evaluation of reconstructed images and left ventricular parameters were conducted to further optimize the parameters of the algorithm and to provide a way of evaluating MEE with a single PET scan.