基于微针的生物检测与诊疗

生物芯片技术和纳米功能材料的快速发展为生物传感器的性能提升、高度自动化、微型化、集成化与移动便携性提供了坚实基础，特别是将传感器与可穿戴器件结合，利用无创或微创式手段对人体医学生理参数进行原位实时连续监测将成为未来发展的必然趋势。微针作为一种新型的微创式治疗平台曾被用于药物或疫苗的经皮递送。近年，随着生物传感技术的进步和个性化医学诊断的需求，科学家们尝试将微针平台应用于生物传感领域，得力于其特别适合实现单次经皮检测或者长期可穿戴式健康监测的优势。本项目拟从新型纳米生物传感材料与组件在阵列式载药微针平台的集成设计入手，系统研究载药微针在皮肤组织内的多层次生物-材料界面效应，传感反馈机制下的经皮药物控释与代谢机制，并借助体外细胞组织模型和动物体内实验指导下的功能验证与性能优化，最终实现基于阵列式微针的可穿戴微创医学检测平台,且具有传感反馈功能的智能诊疗一体化新技术。

The development of biochip technology and functional nanomaterials has significantly improved the performance, automation, miniaturization, integration and portability of biosensors. It is a current trend to integrate biosensors with wearable devices to realize in-situ and real-time monitoring of biomedical parameters from human body in a noninvasive or minimally-invasive fashion. Previously, microneedle arrays have been applied as a novel and minimally-invasive platform for transdermal delivery of therapeutic drugs or vaccines. Recently, many scientists have attempted to integrate biosensors with microneedle arrays for wearable and long-term monitoring of important physiological conditions, which is a highly desirable feature towards personalized healthcare. In this proposal, the applicant plan to integrate novel biosensors and theranostic nanoagents on microneedle arrays, and use this platform to study the multiple interactions between the sensor/drug-loaded microneedles and the dermal cells or tissues in vitro and in vivo, as well as the controlled release mechanism under the feedback of biosensors. The aim of this study is to develop a wearable and biosensor-controlled theranostic device based on the minimally-invasive microneedle arrays.