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机舱表面接触网络中的病毒传播机理和防控措施研究及验证

批准号:
82103963
项目类别:
青年科学基金项目(C类)
资助金额:
30.0 万元
负责人:
肖胜蓝
依托单位:
学科分类:
预防医学研究新技术与新方法
结题年份:
2024
批准年份:
2021
项目状态:
已结题
项目参与者:
肖胜蓝

项目摘要

结项摘要

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中文摘要
新发突发传染病疫情在全球范围内频频发生,严重危害人类健康和社会稳定。全球传染病的传播范围和全球航班形成的交通网络密切相关,因此飞机机舱内的传染病传播需要引起足够的重视。表面接触传播是机舱内病毒的主要传播途径之一,然而病毒的表面传播机理尚未明晰,导致缺乏基于证据的防控措施。申请人前期进行了飞机模拟舱内人员行为观察实验,发现机舱内的表面接触网络具有拓扑结构复杂并且节点异质性高的特点,但这些特点对病毒传播机理和防控措施的影响尚不明确。本课题拟针对空间封闭、人群密度高及环境表面种类繁多的机舱环境,基于机舱人员行为观察数据,采用理论分析、模拟实验和计算机仿真相结合的办法,探索病毒在表面接触网络的时间-空间分布规律,揭示网络拓扑结构与节点性质对病毒传播的动态作用规律,明晰与验证不同防控措施在病毒传播过程中起到的独立作用与协同作用。研究结果将有助于改善机舱环境并降低人群感染风险,科学精准地防控疫情。
英文摘要
Emerging infectious diseases occur frequently worldwide, seriously jeopardizing human health and social stability. The global spread of infectious diseases is closely related to the transportation network formed by global flights. Therefore, the spread of infectious diseases in aircraft cabins requires more attention. Fomite route is one of the main transmission routes of viruses in the aircraft cabins. However, the mechanisms of virus fomite transmission are not clear, leading to a lack of evidence-based control measures. Our previous experiments indicated that the surface touch network in the aircraft cabins has complex topological structure and heterogeneous node properties. Nevertheless, the potential virus transmission mechanisms underlying these characteristics and the corresponding control measures exploiting these characteristics have not been investigated yet. This project is intended for the aircraft cabin environments with closed space, high crowd density and wide variety of environmental surfaces. Based on the observation data of the behavior of people in the aircraft cabin, a unified research framework consisting of theoretical analysis, laboratory experiment and computer simulations will be proposed and carried out to explore the temporal-spatial distribution of viruses. The project will reveal the dynamic effects of surface touch network topology and node properties on virus transmission, as well as clarify and verify the independent and synergistic effects of different control measures in the virus transmission. The results will help to improve the aircraft cabin environment, reduce the infection risk of the susceptible, and control the epidemic scientifically and accurately.
本项目针对机舱环境中病毒在表面的传播规律及防控措施有效性问题,构建了异构表面接触网络理论模型,揭示了表面污染范围和浓度的动态传播规律,推导出耦合清洁阈值标准,表明手和表面病原体去除率乘积需超过阈值才能实现污染的指数衰减。通过荧光粒子和H1N1病毒实验,研究了病毒在不同材料表面、环境条件和接触模式下的转移特性,发现高风险区域(如过道座椅靠背等)的污染扩散迅速且风险显著。基于多主体仿真技术,模拟了国际航班机舱内病毒的多途径传播,结果表明远距离气溶胶传播占感染风险的75%以上,表面接触传播风险虽低但在高接触频率区域具有放大效应。研究表明佩戴N95口罩可将感染风险降低47.88%,并提出了针对复杂场景的精准防控措施。本项目通过理论建模、实验验证和多主体仿真相结合的方法,系统量化了病毒传播的物理机制及防控措施的适用性,为交通运输、公共场所等高风险环境的卫生管理和防疫优化提供了理论支持和实践指导。项目成果已发表SCI论文6篇,其中在《Journal of Hazardous Materials》《Journal of Hospital Infection》《American Journal of Infection Control》等JCR一区论文发表论文4篇,研究成果获国际健康建筑权威会议Healthy Buildings 2023 Asia学生会议支持奖,并授权专利1项,为公共卫生安全和疫情防控提供了理论创新和应用价值。
基于儿科病房表面接触网络特征的病原 体传播机理与差异化防控措施研究
  • 批准号:
    --
  • 项目类别:
    省市级项目
  • 资助金额:
    10.0万元
  • 批准年份:
    2025
  • 负责人:
    肖胜蓝
  • 依托单位:
国内基金
海外基金