海马体内记忆存储和提取的动力学建模分析与调控

对海马体存储和提取记忆机制的研究一直是个热点问题，模式分离和模式完成是存储和提取记忆的关键环节。海马体内存在着形状、位置、连接性和内在属性等方面都有着较大差异的神经元，即异质性神经元。目前，关于异质性神经元对海马体存储和提取记忆影响的研究还较少。本项目拟利用非线性动力学的理论和方法，构建海马体的齿状回和CA3区域内的异质性神经元的多房室动力学模型，分析其放电动力学特性并给出简化模型；在此基础上，建立齿状回和CA3异质性神经元网络，讨论异质性神经元对齿状回的模式分离和CA3的模式完成过程的影响，揭示其发生的动力学机制，并探究其他因素和异质性神经元对这两个过程的协同调控作用；进而阐述异质性神经元在海马体存储和提取记忆中扮演的重要角色。本项目属于非线性动力学和神经科学的交叉研究，其研究结果不仅对揭示大脑存储和提取记忆的机制有重要的理论意义和研究价值，也为研究其他脑功能的工作机制奠定了理论基础。

The mechanisms of memory storage and retrieval in hippocampus has always been a hot research topic. Pattern separation and pattern completion are found to play important role in the process of memory storage and retrieval. There are different neurons in the shape, location, connectivity and internal attributes in the hippocampus, namely heterogeneous neurons. At present, there are few studies about the effect of heterogeneous neurons on the storage and retrieval of memory in hippocampus. In this project, the theory and method of non-linear dynamics are used to build a multi-compartment dynamical model of heterogeneous neurons in dentate gyrus and CA3 sub-region of hippocampus. We will analyze their firing dynamical characteristics and give a simplified model; Based on this, the network of dentate gyrus and CA3 neuronal network containing heterogeneous neurons are established. Using the established models, we will discuss effects of heterogeneous neurons on pattern separation of dentate gyrus and pattern completion of CA3 and try to give underlying mechanisms of the observed phenomena. Then, we move to investigate the regulated function of other factors and heterogeneous neurons on these two processes. With these studies, significant roles of heterogeneous neurons in the storage and retrieval of memory in the hippocampus are revealed. This project belongs to the cross research of nonlinear dynamics and neuroscience. The research results not only have important theoretical significance and research value for revealing the mechanism of memory storage and retrieval, but also lay a theoretical foundation for studying the working mechanism of other brain functions.