基于抗蛋白吸附及免疫调控双重机制的抗异物反应涂层研究

异物反应是可植入生物材料在应用中所面临的重大挑战，如何构建表面涂层以有效防止异物反应仍然是植入式医疗器械研发过程中难以解决的关键问题。针对异物反应发生过程机理，本项目创新性的提出了将抗蛋白吸附机理与主动免疫调控机制相结合的策略，通过涂层材料结构设计实现两种机制的协同，达到在实际应用场景下对植入物异物反应的抑制。项目依托超声喷涂技术平台，将探索制备具有自主创新特点的混合电荷聚电解质抗吸附凝胶涂层，并在涂层当中集成免疫细胞调控功能基团。系统研究材料组成结构对涂层抗蛋白吸附能力的影响；探究免疫调控涂层与免疫细胞之间的作用机制；在动物模型中评价涂层的抗异物反应能力，并以连续型血糖监测仪为模型植入器械，评价新型涂层技术的转化应用前景。

Foreign body response is a major challenge in the application of implantable biomaterials. How to construct a surface coating to effectively prevent foreign body response remains as a key problem in the development of implantable medical devices. Herein, we propose a novel strategy to resist foreign body response in actual application scenarios by synergistically combining anti-protein adsorption and immunomodulation mechanisms in a stable surface hydrogel coating. Based on an ultrasonic spray technology platform, the study will build an innovative mixed-charge polyelectrolyte anti-adsorption gel coating, integrating immune cell modulatory functional groups; systematically investigate the effects of material composition on the anti-protein adsorption property of the coating; explore the mechanism of action between the immune modulatory coating and immune cells; evaluate the resistance of foreign body response by the coating in an animal model; and use a continuous blood glucose monitor as a model device to evaluate the translational potential of the new technology.