电子螺旋理论指导下手性自具微孔聚合物膜的设计合成及分离性能研究

发展高效手性拆分技术是高端制药工业发展的热点和难点。手性膜分离作为一种易于工业放大和低能耗的手性拆分技术，被认为是最可能解决手性分离难题的手段。然而，兼有高通量和高选择性的稳定手性膜材料，迄今尚难实现。本项目以分析手性相互作用的电子螺旋理论为指导，以高通量自具微孔聚合物为材料基础，设计了一类兼有手性螺二茚满骨架和手性伯胺官能团的自具微孔有机聚合物（PIM-NH2）材料，制备成膜并用于小分子对映体的选择性分离。通过调控微观结构，和优化反应条件，制备具有高比表面积和良好溶剂可溶性的聚合物分子；在此基础上制备出同时具有高通量和高选择性的手性拆分膜，通过对分离过程的分析，建立分离动力学模型，阐明聚合物分子结构和膜分离性能的内在联系。该项目实施将开拓自具微孔聚合物膜新的应用领域，为高性能手性膜分离技术的发展提供新材料、新思路和新方法。

The development of high-efficiency chiral separation technology is critical for the development of high-end pharmaceutical industry. Chiral membrane separation, which is easy to scale-up and low in energy consumption, is considered to be the best solution for chiral separation. However, stable chiral membrane materials with both high throughput and high selectivity have so far been difficult to achieve. This project based on an electronic helix theory which is good for analysis of chiral interactions, and polymers of intrinsic microporosity (PIMs) which have high-throughput properties, designed a class of PIMs with both chiral spirodiindane skeleton and chiral primary amine functional groups. The material is prepared into a membrane and used for the selective separation of small molecule enantiomers. By adjusting the microstructure and optimizing the reaction conditions, polymer molecules with high specific surface area and good solvent solubility were prepared. On this basis, a chiral resolving membrane with high throughput and high selectivity was prepared, and Based on the analysis of the separation process, a separation kinetic model was established to clarify the inherent relationship between the molecular structure of the polymer and the separation performance of the membrane. The implementation of this project will open up new application fields of PIM membranes, and provide new ideas, new methods as well as new materials for the development of high-performance chiral membrane separation technology.