FAM83H-AS1通过FAM83H调控Wnt/β-catenin信号通路促进胰腺癌转移及其机制研究

对于胰腺癌转移机制的深入研究和阐释有利于改善胰腺癌的不良预后。长链非编码RNA（lncRNA）广泛参与多种生理和病理过程的调控，可能在胰腺癌转移的调控中发挥着重要作用。我们利用公共数据筛选到了调控胰腺癌转移的关键lncRNAs，并验证了它们作为胰腺癌早期诊断标志物及预后判断指标的潜能。进一步地，实验结果显示FAM83H-AS1对胰腺癌转移表现出明显的促进作用，并且与其正义链基因FAM83H在胰腺癌中存在相互作用。下一步的研究工作中，我们将重点探究FAM83H-AS1调控FAM83H表达的分子机制，同时阐明FAM83H是否通过直接结合并抑制β-catenin的泛素化降解，进而激活Wnt/β-catenin信号通路，实现对胰腺癌转移的调控。系统阐明FAM83H-AS1/FAM83H/β-catenin信号轴对胰腺癌转移的影响及作用机制，可能会为胰腺癌的治疗方案提供新的证据和干预靶点。

Deep research and interpretation of the mechanism through which pancreatic cancer metastasis initiates and progresses is beneficial for the improvement of the poor prognosis of pancreatic cancer. Long non-coding RNA (lncRNA) is involved in the regulation of various physiological and pathological processes and may play important roles in regulating pancreatic cancer metastasis. We screened the key lncRNAs that regulate pancreatic cancer metastasis using the public data, and further verified their potentials as early diagnostic markers and prognostic indicators for pancreatic cancer. Furthermore, the experimental results showed that FAM83H-AS1, interacting with its sense transcript FAM83H, significantly promoted pancreatic cancer metastasis. Next, our researching work will focus on the exploring the molecular mechanism FAM83H-AS1 regulating FAM83H expression. At the same time, we will clarify whether FAM83H directly binds with β-catenin and inhibits its ubiquitination and degradation, thereby activating the Wnt/β-catenin signaling pathway and regulating the metastasis of pancreatic cancer. To clarify the mechanism through which FAM83H-AS1/FAM83H/β-catenin signal axis regulates pancreatic cancer metastasis may provide new evidences and therapeutic strategies for the treatment of pancreatic cancer.