糖胺聚糖类似物化学组成和拓扑结构协同作用构建血液相容性高分子材料

优异的血液相容性是血液接触材料成功应用的关键。然而截至目前，真正意义上血液相容的物质只有健康的血管内壁。天然血管结构具有独特的多尺度微纳米复合结构，此外血管内皮表面丰富的糖胺聚糖（GAGs）能最大程度地保护血管，维持其血液畅通。受此启发，本项目利用GAG类似物的化学组成和拓扑结构的协同效应制备具有优异血液相容性的聚二甲基硅氧烷（PDMS）材料。首先，同步结合多组分热固化工艺和复制模塑法制备具有有序图案结构和微纳米复合结构的含溴引发剂的PDMS表面（PDMS-Br）。然后通过可见光诱导接枝聚合，在具有不同拓扑结构的PDMS-Br表面引入GAG类似物。同时通过图案化金膜转印和金-硫键自组装制备具有异质化学组成的GAG类似物改性表面。拟研究GAG类似物化学组成和拓扑结构双重因素对血液相容性的影响规律及其作用机制。GAG类似物化学组成和拓扑结构的有机结合为制备血液相容性材料提供了新方法和新思路。

Excellent blood compatibility is required for the successful application of blood-contacting materials. Unfortunately, the healthy endothelium is the only known surface that is blood compatible in all respects. Natural blood vessels have unique multi-scale micro-nano composite structures. In addition, the abundant glycosaminoglycans (GAGs) on the surface of vascular endothelium can ultimately protect the blood vessels and keep the blood flowing. Inspired by the chemical and topographical features of the vascular endothelium, we aim to develop poly(dimethylsiloxane) (PDMS) materials with improved hemocompatibility by combining the chemical composition and surface topography of GAG mimetics in a biomimetic way. A facile method to produce bromine-containing PDMS surface (PDMS-Br) with topographical features (surface patterning and micro-/nanoscale surface topographies) will be developed by a one-step multicomponent thermocuring procedure and replica molding. Different GAG mimetics will be introduced on the flat and topographical PDMS-Br surface by visible light-induced graft polymerization. In addition, air plasma assisting microcontact deprinting and printing transfer approaches will be used to fabricate gold film patterns and PDMS patterns. Then differernt GAG mimetics may be introduced in the areas of gold film patterns and PDMS patterns, respectively, to form hetergenerous patterned surfaces modified with GAG mimetics. The influence of chemical compisition and surface topography of GAG mimetics on the hemocopatibility of the modified surfaces will be investigated. The possible mechanism will also be discussed. A biomimetic principle that combining chemical composition and surface topography of GAG mimetics may provide a new strategy to design blood compatible materials.