谱系示踪Sca1血管干细胞在动脉粥样硬化中的作用研究

目前心血管疾病的患病率和死亡率一直为各类疾病之首，心血管疾病发病率高且治愈率低，近年来一直呈上升态势，如今已经成为人类健康的头号杀手之一。研究动脉粥样硬化中干细胞的作用对于该疾病的治疗和预防具有重要意义.前期研究表明，Sca1可以标记血管外多种细胞类型，而Sca1+细胞在特定情况下可以发生转分化和谱系变化,但其在动脉粥样硬化中的命运转变和功能作用并不明确。我们的研究将利用分子生物学技术与转基因小鼠模型相结合，深入研究Sca1+细胞在动脉粥样硬化疾病进程中的细胞谱系变化和功能作用，并探索其调控动脉粥样硬化进程的分子机制，为动脉粥样硬化的治疗提供新方向，从而为心血管再生医学提供新思路。

At present, the morbidity and mortality of cardiovascular diseases are the leading cause of various diseases. The incidence rate of cardiovascular diseases is high and the cure rate is low. It has become one of the leading killer of human health. It is very important to study the role of stem cells in atherosclerosis for the treatment and prevention of the disease. A number of in vitro studies have shown that Sca1+ cells can undergo transdifferentiation under specific conditions. At the same time, Sca1 can label a variety of cells outside the blood vessels, but its function in atherosclerosis are not clear. Our research will focus on combines the molecular biological technology with the transgenic mouse model to study the cell lineage 、 function of Sca1+ cells in the process of atherosclerosis and explore the molecular mechanism.It may provide a new direction for the treatment of atherosclerosis, and then we can provide a new idea for cardiovascular regenerative medicine.