基于手性离子液和泡沫逆流色谱的手性分离新技术研究

如何高效获得单一对映体一直是手性分离领域研究的热点和难点之一。但是实现快速、高效的手性分离过程的相关研究进展较为缓慢，限制了单一对映体的分离，亟需有新的手性分离技术为其提供技术支持。本项目拟合成系列带有长烷基侧链的手性离子液，利用该类手性离子液同时具有表面活性和立体选择性的特性，结合逆流色谱极大的螺旋管长径比和强离心力场对泡沫分离效率的增强作用，借助泡沫逆流色谱连续分离的特点，构建一种基于手性离子液和泡沫逆流色谱的动态连续逆流色谱手性分离新技术。系统研究该手性分离技术中操作参数、化合物物化性质与对映体手性分离行为（ee%值、R值、E值）之间的相互联系，并结合理论计算深入探讨化合物结构与手性分离行为之间的关系，进一步考察影响手性分离效率的因素，为手性化合物分离提供新的技术平台，推动新型手性分离技术与相关基础理论的发展，为新的手性分离过程的设计和放大提供理论指导和技术支撑。

It is one of the difficult and hot spots in chiral separation field to efficiently obtain a single enantiomer. However, the development of rapid and efficient chiral separation and related research in this field is a slower process, which limits the separation of enantiomers. This problem is crying out for some novel chiral separation technologies. This project plans to synthesize series chiral ionic liquids with long alkyl side chains to take advantage of surface activity and stereoselectivity of this kind of chiral ionic liquid, combining it with the large length to diameter ratio and the bubble separation efficiency enhancement by external centrifugal force field of foam counter-current chromatography, establishing a dynamic continuous foam chiral separation technology based on chiral ionic liquid and foam counter current chromatography with the aid of continuous separation characteristic of foam counter-current chromatography. And then systematically investigate the correlation among foam counter-current chromatography operating parameters, physical properties of enantiomers and chiral separation chromatographic retention behavior (ee%, R and E values) at macro level. Meanwhile, this work will in-depth explore the relationship between chemical construction and chiral separation behavior by theoretical calculation. And examine the factors which have most influence on the efficiency of chiral separation. These works will provide new ideas and technical support for quick, efficient, continuous chiral separation. Also provide theoretical guidance and technical support for novel design and scale of chiral separation process.