HOP1和HOP2调控植物生长与耐盐平衡的分子机制研究

植物生长与抗逆的动态平衡是植物增产抗逆的关键。挖掘抗逆基因并解析其分子调控机理对培育高产耐逆作物品种具有重要指导意义。辅助分子伴侣在蛋白折叠过程中发挥重要作用，进而可能影响植物的正常生长发育和逆境胁迫响应。但植物如何通过辅助分子伴侣调控植物生长与耐逆的动态平衡尚不清楚。项目前期研究发现辅助分子伴侣HOP1和HOP2受盐诱导；在低浓度盐胁迫下，hop1 hop2突变体表现出盐敏感表型；外源施加植物激素油菜素内酯（BRs）能够提高突变体hop1 hop2的耐盐能力。因此，我们猜测油菜素内酯可能参与调控HOP1和HOP2的盐胁迫应答反应。本项目将通过解析HOP1、HOP2与油菜素内酯信号交叉调控的分子机理，逐步阐明HOP如何整合内源激素信号和外界盐胁迫信号调控植物生长与耐盐的平衡，进而为培育高产耐盐作物提供理论基础和借鉴意义。

The dynamic balance between growth and stress resistance is crucial for the high yield and stress-tolerance of crops. Discovering stress-tolerant genes and analyzing their molecular mechanism have a great guiding significance for the cultivation of high-yield and stress-tolerant crops. Co-chaperones play an important role in the process of protein folding, which may affect plant growth, development, and stress responses. However, the mechanism underlying the balance between growth and stress resistance through co-chaperones has remained elusive. In our previous study, we found HOP1 and HOP2 of co-chaperones HOP family were induced by the salt signal. The hop1 hop2 mutant was sensitive to even a low concentration of salt. While the exogenous application of BR could improve the salt tolerance. Therefore, brassinosteroid may be involved in regulating the salt stress response of HOP1 and HOP2. In this project, the cross-talk between HOP1, HOP2, and brassinosteroid signals will be analyzed. Our long-time goal is to gradually clarify the molecular mechanisms by which HOP regulating network integrates endogenous hormone signals and external salt stress signals to regulate the balance between plant growth and salt tolerance. This provides the theoretical basis and reference significance for the cultivation of high-yield and salt-tolerant crops.