乳突状甲状腺癌（PTC）是一种常见的内分泌系统恶性肿瘤。PTC按其侵袭性大致分为高危和低危两大类。叉头盒蛋白E1（FOXE1）表达降低是PTC向未分化型甲状腺癌转变的重要过程。我们发现：中国北方汉族PTC患者FOXE1 3' UTR单核苷酸多态性位点rs1443434和rs965513与PTC风险相关。据此我们提出以下假说：与FOXE1基因多态性3' UTR特异性结合的miRNA的表达差别可能是导致PTC向未分化型甲状腺癌转变的原因。本项目旨在：⑴确证与FOXE1基因多态性3'UTR特异性结合的目标miRNAs的靶向调控作用，为PTC的病因学研究提供证据。⑵通过检测高危和低危的PTC患者以及正常人群血浆中与FOXE1 3'UTR结合的目标miRNA水平，作为PTC不同临床表型的miRNAs标志物，探索针刺检查造成癌细胞扩散等病理检查问题的解决途径，为不同表型的PTC预防和控制提供监测指标。

Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy, including benign and malignant clinical phenotypes. The low expression of forkhead box E1 (FOXE1) is essentially involved in transformation of benign phenotypes to malignant phenotypes. Our previous investigation revealed rs1443434 and rs965513 in FOXE1 3' UTR were associated with PTC. Therefore, we propose hypothesis of this project: miRNAs specific to SNPs of FOXE1 3' UTR contributes to the transformation of benign phenotypes to malignant phenotypes. In this project, we shall validate target-regulating of miRNAs specific to SNPs of FOXE1 3' UTR, providing etiological evidence for PTC. Furthermore, we shall measure the levels of miRNAs specific to SNPs of FOXE1 3' UTR, and investigate those miRNAs as potential biomarker of benign phenotypes and malignant PTC.