芳香环化合物来源广泛，原料易得，对其直接的不对称去芳香化反应已经发展为构建手性化合物的有效策略。Ireland-Claisen重排是一类具有重要合成价值的反应，可以立体专一性地将相对容易获得的C-O键转化为难于构建的C-C键。本项目基于将这两个重要反应相结合的新思路，在一个催化剂的作用下，同时实现吲哚类底物的不对称去芳香化反应和Ireland-Claisen重排反应，从而高效构筑具有多个手性中心的吲哚啉类化合物。旨在进一步拓宽丰富不对称去芳香化反应的反应类型和底物适用范围，同时探索并希望解决Ireland-Claisen重排反应难于实现不对称催化的问题。

Arenes compounds are kinds of readily available, widely existing starting materials, which could be applied to construct complex chiral organic molecules via catalytic asymmetric dearomatization strategy. The Ireland–Claisen rearrangement remains a synthetically useful reaction in organic synthesis due to its potentiality to transform an easily accessed ester C-O bond into a more valuable C-C bond in a stereoselective fashion. This project is mainly based on the combination of these two important reactions and intends to use single catalyst realizing the catalytic asymmetric dearomatization and Ireland-Claisen rearrangement of indole derivatives, namely to construct chiral multi-stereocenters substituted indoline compounds. Our goal is to further broaden enantioselective dearomatization reaction types and substrate scopes, at the same time to explore and realize catalytic asymmetric version of Ireland-Claisen rearrangment reaction.