高危型HPV自然感染者抗体产生、持续、消除的动力学及临床意义研究

高危型人乳头瘤病毒(HPV)感染可导致子宫颈等部位癌症，HPV自然感染后诱导的抗体应答对病毒持续、清除、传播及转归产生重要影响，现有相关数据少且结论不一。2019年底国产宫颈癌疫苗上市使得我国推广HPV疫苗接种成为可能，HPV自然免疫抗体特性是疫苗成本效益分析的重要参数。我国HPV感染特征与发达国家有较大差异，除性生活模式差异外，自然免疫也与此密不可分，需依据本土流行病学数据制定最优免疫策略。本研究拟通过对18-45岁自然健康妇女的长期随访，结合既往已获得的高质量HPV DNA及细胞学、病理学随访数据，阐明HPV自然感染诱导的抗体免疫应答的人群特征，抗体产生、持续、清除的动力学特征、年龄别差异及影响因素、自然抗体对同型新发感染的保护效应及其对疾病转归的影响，以期深入地理解自然免疫在HPV自然史中的作用，为制订适合我国的HPV疫苗应用策略提供科学依据。

High-risk human papillomavirus (HPV) infection is the cause of cervical cancer, naturally acquired antibodies to high-risk HPV have great impact on the persistence, clearance, transmission of HPV and the clinical outcomes, related data is scarce and inconsistent. The first domestic HPV vaccine was licensed last year which made wide coverage of HPV vaccination became possible, and HPV natural immunity is one of the key parameters of vaccine cost-effectiveness analysis. The characteristics of HPV infection in China differ greatly from those in the developed countries, in addition to sexual activities, natural immunities to HPV also play roles. Through long-term follow-up of healthy Chinese women aged 18 to 45 years old, combining with the data of HPV DNA infection, cytological and pathological findings, we will clarify the dynamics, including the seroconversion, persistence, clearance of naturally acquired antibodies to HPV and related impact factors, their protection against future infection of the same type, their impact on clinical outcomes in different age groups, to further understand the natural history of HPV, and provide basic data for making HPV vaccination strategies.