Recovery from Proactive Semantic Interference and MRI Volume: A Replication and Extension Study
Recovery from Proactive Semantic Interference and MRI Volume: A Replication and Extension Study
复制标题
DOI：
10.3233/jad-170276
复制
发表时间：
2017-01-01
影响因子：
4
通讯作者：
Duara, Ranjan
中科院分区：
文献类型：
--
作者：
Loewenstein, David A.;Curiel, Rosie E.;Duara, Ranjan
背景：阿尔茨海默病（AD）发病率的上升促使人们努力在临床前阶段早期发现这种疾病。为了实现这一目标，该领域需要开发与疾病病理学的生物标志物有关的更敏感的认知测试。未能从主动干扰中恢复（frPSI）就是这样一种认知标志，它与海马、楔前叶和其他ad易发区域的体积减少以及大脑中淀粉样蛋白负荷有关。目的：本研究试图复制和扩展我们之前的研究结果，即frPSI是早期AD的敏感标志物，并且与AD易发区域的独特体积损失模式有关。方法：对45例轻度遗忘性认知障碍患者进行三种不同的记忆测量，并与体积损失和皮质厚度进行比较。结果：frPSI与海马（r = 0.50）楔前叶（r = 0.41）和其他AD易发区域的体积减少有独特的相关性，与先前的研究结果重复。frPSI与下内嗅皮质体积和皮质厚度（r >= 0.60）和楔前叶（r = 0.50）之间也有很强的相关性。结论：Loewenstein和他的同事所观察到的体积减小和frPSI之间独特而强烈的联系是重复的。结合皮层厚度的发现，这些结果表明frPSI作为阿尔茨海默病的敏感和早期认知标志物值得进一步研究。
Background: The rise in incidence of Alzheimer's disease (AD) has led to efforts to advance early detection of the disease during its preclinical stages. To achieve this, the field needs to develop more sensitive cognitive tests that relate to biological markers of disease pathology. Failure to recover from proactive interference (frPSI) is one such cognitive marker that is associated with volumetric reductions in the hippocampus, precuneus, and other AD-prone regions, and to amyloid load in the brain.Objective: The current study attempted to replicate and extend our previous findings that frPSI is a sensitive marker of early AD, and related to a unique pattern of volumetric loss in AD prone areas.Methods: Three different memory measures were examined relative to volumetric loss and cortical thickness among 45 participants with amnestic mild cognitive impairment.Results: frPSI was uniquely associated with reduced volumes in the hippocampus (r = 0.50) precuneus (r = 0.41), and other AD prone regions, replicating previous findings. Strong associations between frPSI and lower entorhinal cortex volumes and cortical thickness (r >= 0.60) and precuneus (r = 0.50) were also observed.Conclusion: Unique and strong associations between volumetric reductions and frPSI as observed by Loewenstein and colleagues were replicated. Together with cortical thickness findings, these results indicate that frPSI is worthy of further study as a sensitive and early cognitive marker of AD.