Diagnostic efficiency of68Ga-DOTANOC PET/CT in patients with suspected tumour-induced osteomalacia
Diagnostic efficiency of68Ga-DOTANOC PET/CT in patients with suspected tumour-induced osteomalacia
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DOI：
10.1007/s00330-020-07342-2
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发表时间：
2020-10-06
影响因子：
5.9
通讯作者：
Zhang, Xiangsong
中科院分区：
文献类型：
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作者：
He, Qiao;Zhang, Bing;Zhang, Xiangsong
目的 目前，肿瘤诱发的骨软化症 (TIO) 的主要挑战是难以定位罪魁祸首肿瘤以进行明确诊断和手术治疗。在此，我们回顾性评价(68)Ga-DOTANOC PET/CT在TIO定位和诊断中的效率，并与(18)F-FDG进行比较。方法 对连续 24 例因低磷血症性骨软化症 (HO) 并怀疑 TIO 转诊至我中心进行 (68)Ga-DOTANOC PET/CT 扫描的患者进行回顾性分析。对图像进行定性和半定量评估，并将成像结果与最终诊断进行比较。结果 纳入最终分析的 21 例患者中，17 例被诊断为 TIO，4 例被证明有其他原因导致 HO。17 例 TIO 患者中，Ga-68-DOTANOC PET/CT 对 16 例产生阳性结果，敏感性为 94.1%。此外，4 例无 TIO 的患者中，有 3 例 (68)Ga-DOTANOC PET/CT 结果呈阴性，特异性为 75.0%。 (68)Ga-DOTANOC PET/CT 定位导致 TIO 的肿瘤的总体准确度为 90.5%。特别是，Ga-68-DOTANOC PET/CT 在先前 (18)F-FDG PET/CT 阴性结果的 10 名患者中检测到了 4 名罪魁祸首，并且在同一患者中，肿瘤 T/M 比显着高于 (18)F-FDG PET/CT (n= 10; 4.76 +/- 3.08 vs 1.95 +/- 1.33，p< 0.05）。结论 Ga-68-DOTANOC PET/CT 是 TIO 肿瘤定位的准确成像方式。它优于(18)F-FDG PET/CT，可能有助于 HO 的鉴别诊断。
Objectives Currently, the main challenge in tumour-induced osteomalacia (TIO) is the difficulty in locating culprit tumours for definitive diagnosis and surgical therapy. Herein, we retrospectively evaluate the efficiency of(68)Ga-DOTANOC PET/CT in the localisation and diagnosis of TIO, and compared with(18)F-FDG. Methods Twenty-four consecutive patients with hypophosphataemic osteomalacia (HO) and suspicion of TIO who were referred to our centre for(68)Ga-DOTANOC PET/CT scanning were retrospectively reviewed. The images were evaluated qualitatively as well as semi-quantitatively, and imaging results were compared with the final diagnoses. Results Among the total of 21 patients who were included in the final analyses, 17 were diagnosed with TIO, while four were proven to have other causes of HO.Ga-68-DOTANOC PET/CT produced positive results in 16 of the 17 patients with TIO, representing a sensitivity of 94.1%. Moreover, the(68)Ga-DOTANOC PET/CT results were negative in 3 of the 4 patients without TIO, representing a specificity of 75.0%. The overall accuracy of(68)Ga-DOTANOC PET/CT in locating the tumours responsible for TIO is 90.5%. In particular,Ga-68-DOTANOC PET/CT detected the culprit tumours in 4 out of 10 patients with negative results on previous(18)F-FDG PET/CT and showed a significantly higher T/M ratio of tumours than(18)F-FDG PET/CT in the same patients (n= 10; 4.76 +/- 3.08 vs 1.95 +/- 1.33,p< 0.05). Conclusions Ga-68-DOTANOC PET/CT is an accurate imaging modality in the localisation of tumours for TIO. It is superior to(18)F-FDG PET/CT and may be useful in the differential diagnosis of HO.