Effects of intragastric agmatine on morphine-induced physiological dependence in beagle dogs and rhesus monkeys.
Effects of intragastric agmatine on morphine-induced physiological dependence in beagle dogs and rhesus monkeys.
复制标题
DOI：
10.1016/j.ejphar.2008.03.022
复制
发表时间：
2008-06
影响因子：
5
通讯作者：
R. Su;Xin-qiang Lu;Yu Huang;Yin Liu;Zheng-hua Gong;Xiaocui Wei;N. Wu;Jin Li
中科院分区：
文献类型：
--
作者：
R. Su;Xin-qiang Lu;Yu Huang;Yin Liu;Zheng-hua Gong;Xiaocui Wei;N. Wu;Jin Li
我们以前的研究表明，皮下注射胍丁胺可以抑制小鼠和大鼠对吗啡的耐受和生理依赖。在本研究中，我们进一步评估了胃内(I.G.)胍丁胺对吗啡诱导的小鼠、大鼠、比格犬和恒河猴生理依赖的影响。当胍丁胺(5-40 mg/kg，i.g)在吗啡诱导的生理依赖形成过程中与吗啡合用，可抑制小鼠、大鼠和比格犬纳洛酮催促的戒断症状。此外，胍丁胺(40 mg/kg，ig)对小鼠纳洛酮催促戒断症状有抑制作用。在纳洛酮催促和自然戒断的恒河猴吗啡依赖模型中，胍丁胺(40或80 mg/kg，i.g.)与吗啡合用可抑制生理依赖的形成。在发展成吗啡依赖后，胍丁胺(80 mg/kg，ig.)在7d戒断期内抑制自然戒断综合征。以上结果提示，灌胃给予胍丁胺可抑制吗啡诱导的动物模型的生理依赖。
Our previous studies demonstrated that subcutaneous injection of agmatine inhibits tolerance to and physiological dependence on morphine in mice and rats. In the present study we further evaluated the effects of intragastric (i.g.) administration of agmatine on morphine-induced physiological dependence in mice, rats, beagle dogs and rhesus monkeys. When agmatine (5–40 mg/kg, i.g.) was co-administered with morphine during the development of morphine-induced physiological dependence, it inhibited the abstinent syndrome precipitated by naloxone in mice, rats and beagle dogs. In addition, agmatine (40 mg/kg, i.g.) inhibited the abstinent syndrome precipitated by naloxone in mice when it was administered on the test day. In naloxone precipitated and naturally abstinent morphine dependent model in rhesus monkeys, agmatine (40 or 80 mg/kg, i.g.) inhibited the development of physiological dependence when it was co-administered with morphine. After the development of morphine dependence, agmatine (80 mg/kg, i.g.) inhibited the naturally abstinent syndrome during the 7-d abstinent period. All these results suggested that intragastric administration of agmatine inhibits morphine-induced physiological dependence in animal models.