Optimal follow-up intervals in active surveillance of renal masses in patients with von Hippel-Lindau disease
Optimal follow-up intervals in active surveillance of renal masses in patients with von Hippel-Lindau disease
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DOI：
10.1007/s00330-015-3591-9
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发表时间：
2015-07-01
影响因子：
5.9
通讯作者：
Gennaro, Gisella
中科院分区：
文献类型：
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作者：
Pomerri, Fabio;Opocher, Giuseppe;Gennaro, Gisella
通过从生长曲线确定肿瘤生长率来估计von Hippel-Lindau（VHL）肾肿块（RM）患者的最佳随访（FU）间隔。30个病变（47.6%）被归类为实体瘤（ST），33个（52.4%）被归类为复杂囊肿（CC）。分析了病变体积随时间的变化。对于53个病灶，我们计算了病灶体积变化最快期间的生长速率，并将其称为快速生长速率（FGR）。ST最初生长较快，随后生长较慢。CC的体积随时间变化，与其流体组分的可变量相关。ST组FGR与最新容积的相关性（r = 0.905）优于CC组（r = 0.780）。通过结合从曲线计算的FGR和最新测量的体积，得出3至12个月之间的最佳FU间隔。分析VHL患者中RM的生长曲线和相关动力学参数可能有助于优化后续FU间隔和改进主动监测程序。肿瘤的体积以典型的S形曲线增加。复杂的囊肿可以随时间自发地增加和减少体积。实体瘤的快速生长速率与其最近的体积相关。快速生长速率可以指导后续随访的安排。
To estimate an optimal follow-up (FU) interval for von Hippel-Lindau (VHL) patients with renal masses (RMs) by determining tumour growth rates from growth curves.Thirty lesions (47.6 %) were classified as solid tumours (STs) and 33 (52.4 %) as complex cysts (CCs). Variations in lesion volume over time were analyzed. For 53 lesions, we calculated the growth rate during the period when the volume of the lesion changed most rapidly, and called this the fast growth rate (FGR).The STs initially grew fast, followed by a period of slower growth. The CCs varied in volume over time, associated with variable amounts of their fluid component. The FGR correlated better with the latest volume for STs (r = 0.905) than for CCs (r = 0.780). An optimal FU interval between 3 and 12 months was derived by combining the FGR calculated from the curve with the latest volume measured.Analyzing growth curves and related kinetic parameters for RMs in VHL patients could be useful with a view to optimizing the subsequent FU interval and improving the active surveillance program.aEuro cent Measuring volume changes over time enables tumour growth curves to be charted.aEuro cent Renal solid tumours increase in volume with a typical sigmoidal curve.aEuro cent Complex cysts may increase and decrease in volume spontaneously over time.aEuro cent The fast growth rate of solid tumours correlates with their latest volume.aEuro cent The fast growth rate can orient the scheduling of subsequent follow-ups.