Genetics of the sudden infant death syndrome
Genetics of the sudden infant death syndrome
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DOI：
10.1016/j.forsciint.2010.07.008
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发表时间：
2010-12-15
影响因子：
2.2
通讯作者：
Madea, Burkhard
中科院分区：
文献类型：
--
作者：
Courts, Cornelius;Madea, Burkhard
婴儿猝死综合征（SIDS）目前被定义为“1岁以下婴儿的突然意外死亡，致命事件明显发生在睡眠期间，经过彻底调查仍无法解释”。小岛屿发展中国家的病因仍然相当模糊，仍然是工业化国家1个月至1岁婴儿死亡的主要原因，在不同人群中的发病率各不相同。在此，在触及定义的方法和目前的几个假说，关于小岛屿发展中国家的病因，我们专注于三重风险模型的小岛屿发展中国家和讨论两大类遗传因素可能有助于或诱发产生一个脆弱的婴儿，当遇到环境触发，可能会屈服于小岛屿发展中国家。最后，我们承认，为整合有关小岛屿发展中国家的巨大而复杂的遗传证据，将需要更多的研究，我们简要讨论了潜在的使用最近提出的动物模型的小岛屿发展中国家的病理功能研究。(C)2010爱思唯尔爱尔兰有限公司版权所有。
The sudden infant death syndrome (SIDS) is currently defined as "the sudden unexpected death of an infant less than 1 year of age with onset of the fatal episode apparently occurring during sleep, that remains unexplained after a thorough investigation''. SIDS, whose etiology remains rather vague, is still the major cause of death among infants between 1 month and 1 year of age in industrialized countries with varying incidences in different populations. Herein, after touching on definitory approaches and several current hypotheses concerning SIDS etiology, we focus on the triple risk model of SIDS and discuss two large classes of genetic factors potentially contributing to or predisposing for the generation of a vulnerable infant that, when encountering an environmental trigger, may succumb to SIDS. We conclude by acknowledging that for the integration of the vast and complex genetic evidence concerning SIDS, a lot more research will be required and we briefly discuss the potential use of recently presented animal models for functional studies of SIDS pathology. (C) 2010 Elsevier Ireland Ltd. All rights reserved.