GENETIC DISSECTION OF CONSOLIDATED MEMORY IN DROSOPHILA
GENETIC DISSECTION OF CONSOLIDATED MEMORY IN DROSOPHILA
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DOI：
10.1016/0092-8674(94)90398-0
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发表时间：
1994-10-07
期刊：
影响因子：
64.5
通讯作者：
DELVECCHIO, M
中科院分区：
文献类型：
--
作者：
TULLY, T;PREAT, T;DELVECCHIO, M
在许多动物物种中进行的行为和药理学实验表明，记忆在训练后的几个小时内从最初的可破坏形式巩固为持久的稳定形式。我们将这些传统方法与果蝇的遗传分析相结合，表明在延长训练后1天，条件（学习）气味回避的巩固记忆由两个遗传上不同的，功能上独立的记忆组成：麻醉耐受记忆（ARM）和长期记忆（LTM）。ARM在4天内腐烂，对低温破坏具有抵抗力，对蛋白质合成抑制剂环己酰亚胺（CXM）不敏感，并且被萝卜单基因突变破坏。LTM在7天内没有明显的衰减，对CXM敏感，并且没有被萝卜突变破坏。
Behavioral and pharmacological experiments in many animal species have suggested that memory is consolidated from an initial, disruptable form into a longlasting, stable form within a few hours after training. We combined these traditional approaches with genetic analyses in Drosophila to show that consolidated memory of conditioned (learned) odor avoidance 1 day after extended training consisted of two genetically distinct, functionally independent memory components: anesthesia-resistant memory (ARM) and longterm memory (LTM). ARM decayed away within 4 days, was resistant to hypothermic disruption, was insensitive to the protein synthesis inhibitor cycloheximide (CXM), and was disrupted by the radish single-gene mutation. LTM showed no appreciable decay over 7 days, was sensitive to CXM, and was not disrupted by the radish mutation.