Precision of the CASL-perfusion MRI technique for the measurement of cerebral blood flow in whole brain and vascular territories
Precision of the CASL-perfusion MRI technique for the measurement of cerebral blood flow in whole brain and vascular territories
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DOI：
10.1002/jmri.10416
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发表时间：
2003-12-01
影响因子：
4.4
通讯作者：
Detre, JA
中科院分区：
文献类型：
--
作者：
Floyd, TF;Ratcliffe, SJ;Detre, JA
目的：为分析连续动脉自旋标记（CASL）灌注磁共振成像（MRI）测量脑血流量（CBF）的精确性，采用1.5T GE Signa磁体，对健康男性和女性受试者分别在1小时和1周时进行CASL灌注MRI测量。测量的精度进行了评价，在这两个时间intervations.Results：CASL灌注MRI测量CBF产生的受试者内的变异系数（wsCV）为5.8%的全球和13%的个别血管区域时，在一个小时内重复测量。这些值的差异表示后处理中的误差。一周内的全球和区域CBF测量结果分别为13%和14%。在一周时，继发于生理变异性的误差对全局和区域测量值的影响程度相同，并掩盖了在一小时时观察到的软件后处理误差。结论：CASL灌注MRI脑血流测量结果准确、精密。在较长时间内的变异性似乎可归因于生理因素。CASL测量的重复性对测量的幅度很敏感。当需要重复测量的研究涉及CBF具有显著变异性的受试者时，应考虑到这一点。
Purpose: To analyze the precision of cerebral blood flow (CBF) measurements made with continuous arterial spin labeling(CASL) perfusion magnetic resonance imaging (MRI) over experimentally relevant intervals.Materials and Methods: CASL perfusion MRI measurements of CBF on a 1.5 T GE Signa magnet were repeated in young healthy male and female subjects atone hour and one week. Precision of the measurement was evaluated at both time intervals.Results: CASL perfusion MRI measurements of CBF yielded within-subject coefficients of variation (wsCV) of 5.8% for global and 13% for individual vascular regions when measurements were repeated within one hour. Differences in these values represent the error in post processing. Global and regional CBF measurements over one week yielded wsCVs of 13% and 14%, respectively. At one week, error secondary to physiologic variability affected global and regional measurements the same degree and masked the software post-processing error seen at one hour. The magnetic of the difference in repeated measures correlated with the magnitude of the measurement.Conclusion:CASL perfusion MRI CBF measurements are accurate and precise. Variability over longer periods of time appears attributable to physiologic factors. Repeatability of the CASL measurement is sensitive to the magnitude of the measurement. This should be taken into account when studies requiring repeated measures involve subjects with significant variability in CBF.