Does the cystometric filling rate affect the afferent bladder response pattern? A study on single fibre pelvic nerve afferents in the rat urinary bladder
Does the cystometric filling rate affect the afferent bladder response pattern? A study on single fibre pelvic nerve afferents in the rat urinary bladder
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DOI：
10.1002/nau.20157
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发表时间：
2006-01-01
影响因子：
2
通讯作者：
Wyndaele, JJ
中科院分区：
文献类型：
--
作者：
De Wachter, S;De Laet, K;Wyndaele, JJ
目的：研究生理和超生理充盈率对大鼠膀胱单纤维盆腔神经传入反应模式的影响。材料和方法：通过电生理学方法鉴定了总共 37 个单个传入膀胱单元，并研究了它们的机械敏感特性。研究了 13 个单位在填充速率为 40 和 200 μl/min 时的传入活动。在 200 和 400 μl/min 下研究了其他单元的传入活动。结果：在 40 μl/min 的生理填充速率下，注意到两种明显不同类型的响应模式。然而，在较高的超生理充盈率下，所有单位都表现出几乎相同的模式。这些单元的机械敏感特性的差异表现出超生理充盈率响应模式的变化，其特征是传入放电率达到峰值时的压力下降。对于所有单元，发现填充速率的增加导致传入单元的激活压力阈值增加，而所有压力下的传入放电速率下降。结论：在大鼠中，超生理充盈率延迟了传入激活，降低了传入放电活动，甚至完全改变了一些传入的特征。这些数据可以阐明在邮件中观察到的动态尿动力学和传统尿动力学之间的一些差异。
Aims: To study the effect of physiological and supraphysiological filling rates on the response pattern of single fibre pelvic nerve afferents of the rat urinary bladder. Materials and Methods: A total of 37 single afferent bladder units were identified electrophysiologically and their mechanosensitive properties studied. Afferent activity of 13 units was studied at filling rates of 40 and 200 mu l/min. Afferent activity of the other units was studied at 200 and 400 mu l/min. Results: At the physiological filling rate of 40 mu l/min two clearly different types of response pattern were noted. However, at higher supraphysiological filling rates, all units exhibited nearly the same pattern. The difference in mechanosensitive properties of the units that showed a change in response pattern at the supraphysiological filling rate, was characterized by a decrease in pressure at which afferent firing rate peaked. For all units it was found that an increase in filling rate induced an increase in the activation pressure threshold for afferent units, whereas the afferent firing rate at all pressures decreased. Conclusions: In rats supraphysiological filling rates delay afferent activation, lower afferent firing activity and even change the characteristics of some afferents completely. These data may elucidate some of the differences between ambulatory and conventional urodynamics observed in mail.