Biochemical characterization of human DNA polymerase iota provides clues to its biological function.
Biochemical characterization of human DNA polymerase iota provides clues to its biological function.
复制标题
人类 DNA 聚合酶 iota 的生化特征为其生物学功能提供了线索。
DOI：
10.1042/0300-5127:0290183
复制
发表时间：
2001
影响因子：
3.9
通讯作者：
Woodgate,R
中科院分区：
文献类型：
--
作者：
Tissier,A;Frank,EG;McDonald,JP;Vaisman,A;FernandezdeHenestrosa,AR;Boudsocq,F;McLenigan,MP;Woodgate,R
人RAD 30 B基因编码一种新的DNA聚合酶--DNA聚合酶。poli在细胞内的作用目前尚不清楚，其细胞功能的唯一线索来自其体外的生化特性，因此，本文简要综述了poli的已知酶活性，并推测这些生化特性与其体内功能的关系。
The humanRAD30Bgene has recently been shown to encode a novel DNA polymerase, DNA polymerasei(poli). The role of poliwithin the cell is presently unknown, and the only clues to its cellular function come from its biochemical characterizationin vitro.The aim of this short review is, therefore, to summarize the known enzymic activities of poli and to speculate as to how these biochemical properties might relate to itsin vivofunction.