COMPUTED DISTRIBUTION OF COPPER(II) AND ZINC(II) IONS AMONG 17 AMINO ACIDS PRESENT IN HUMAN BLOOD PLASMA
COMPUTED DISTRIBUTION OF COPPER(II) AND ZINC(II) IONS AMONG 17 AMINO ACIDS PRESENT IN HUMAN BLOOD PLASMA
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DOI：
10.1042/bj1210549
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发表时间：
1971-01-01
影响因子：
4.1
通讯作者：
WATT, AE
中科院分区：
文献类型：
--
作者：
HALLMAN, PS;PERRIN, DD;WATT, AE
铜（II）和锌（II）离子在17种氨基酸混合物中的平衡分布已由稳定常数和血浆成分数据计算得到。在pH7.4下，模拟血浆溶液中98%的铜（II）与组氨酸和胱氨酸配合，主要以混合配体复合物[Cu·His·胱氨酸]-和[Cu·H·His·胱氨酸]的形式存在。大约一半的锌（II）与半胱氨酸和组氨酸协调，但与大多数其他氨基酸形成明显的络合物。给出了铜（II）和锌（II）氨基酸配合物（包括一些混合配体）在37℃andI=0.15m时的稳定性常数。
The equilibrium distribution of copper(II) and zinc(II) ions among a mixture of 17 amino acids has been computed from stability-constant and blood-plasma-composition data. At pH7.4, 98% of the copper(II) in the simulated plasma solution is co-ordinated to histidine and cystine, predominantly as the mixed-ligand complexes [Cu·His·Cystine]−and [Cu·H·His·Cystine]. Approximately half of the zinc(II) is co-ordinated to cysteine and histidine, but appreciable complex-formation occurs with most of the other amino acids. Stability constants are given for copper(II) and zinc(II) amino acid complexes, including some mixed-ligand species, at 37°C andI=0.15m.