Apolipoprotein E polymorphism in cerebrovascular disease
Apolipoprotein E polymorphism in cerebrovascular disease
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DOI：
10.1034/j.1600-0404.2000.90308a.x
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发表时间：
2000-06-01
影响因子：
3.5
通讯作者：
Grant, PJ
中科院分区：
文献类型：
--
作者：
Catto, AJ;McCormack, LJ;Grant, PJ
目的：本研究的目的是调查载脂蛋白E基因型与急性脑梗死和原发性脑出血之间的关系，并检查载脂蛋白E基因型与急性卒中后死亡率之间的关系。材料与方法我们研究了592例急性中风患者和289名临床上无脑血管疾病的健康对照者。脑卒中的病理类型通过头颅CT确定，脑梗死的亚型根据牛津郡社区卒中项目分类（OCSP）进行分类。采用聚合酶链反应检测载脂蛋白E基因型。结果：病例组和对照组的载脂蛋白E基因型频率无差异（卡方（2）=3.58，5 d.f.，P = 0.60）。载脂蛋白E基因型与卒中的病理类型无关（脑梗死，CI，n = 532，原发性颅内出血，PICH，n = 60，（卡方（2）= 3.738，4 d. f.，P = 0.44），也不符合牛津郡社区卒中项目分类亚型脑梗死、腔隙性梗死、LACI（n = 169）、全前循环梗死、TACI（n = 117）、部分前循环梗死、PACI（n=173）、后循环梗死、POCS（n = 54），包括无法分类的脑梗死（n = 19），chi（2）=31.1，20 d.f.，P = 0.153）。在分析时，243例（41.0%）死亡。中位随访时间（包括死亡）为851天。在CI或PICH病例中，至死亡时间与apo E基因型之间无相关性。结论：在该人群中，载脂蛋白E多态性与脑梗死或原发性脑出血的发病机制无关。载脂蛋白E基因型与卒中后全因死亡率无关。
Objectives - The aim of this study was to investigate the relationship between the apo E genotype with acute cerebral infarction and primary intracerebral haemorrhage and to examine the relationship of the apo E genotype with mortality following acute stroke. Materials and methods We studied 592 cases of acute stroke and 289 healthy control subjects clinically free of cerebrovascular disease. Pathological type of stroke was determined by cranial computed tomography and the subtype of cerebral infarction classified according to the Oxfordshire Community Stroke Project Classification (OCSP). Apo E genotype was determined using polymerase chain reaction. Results - There was no difference in apo E genotype frequency between cases and controls (chi(2)=3.58, 5 d.f., P = 0.60). Apo E genotypes were not related to the pathological type of stroke (cerebral infarction, CI, n = 532 and primary intracranial haemorrhage, PICH, n = 60, (chi(2) = 3.738, 4 d.f., P = 0.44) nor with the Oxfordshire Community Stroke Project Classification subtypes of cerebral infarction, lacunar infarction, LACI (n = 169), total anterior circulation infarction, TACI (n = 117), partial anterior circulation infarction, PACI (n=173), posterior circulation infarction, POCS (n = 54) and including those cerebral infarcts which could not be classified (n = 19), chi(2)=31.1, 20 d.f., P = 0.153). At the time of the analysis, 243 cases (41.0%) had died. The median follow-up (including death) was 851 days. There was no relationship between time to death and apo E genotype in cases of either CI or PICH. Conclusion - In this population, there was no relationship between the apolipoprotein E polymorphism and the pathogenesis of cerebral infarction or primary intracerebral haemorrhage. Apo E genotype was not related to all-cause mortality following stroke.