Pathological Changes During Aging in, Barrier-Reared Fischer 344 Male Rats1
Pathological Changes During Aging in, Barrier-Reared Fischer 344 Male Rats1
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屏障饲养 Fischer 344 雄性大鼠衰老过程中的病理变化1
DOI：
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发表时间：
1977
期刊：
影响因子：
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通讯作者：
A. M. Jonas
中科院分区：
文献类型：
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作者：
G. L. Coleman;S. Barthold;G. Osbaldiston;Sumner J. Foster;A. M. Jonas
摘要：对 144 只 4 至 33 月龄的雄性 Fischer 大鼠进行病理学、微生物学和选定的血清化学分析。大鼠在屏障条件下饲养和维持，成功地排除了整个研究过程中主要传染病病原体的引入，包括肺支原体。人们发现并列出了各种各样的病理学，并且发现许多病变的严重程度和发病率随着年龄的增长而增加。肾脏疾病的严重程度与年龄的增加存在高度相关性。血清总蛋白和白蛋白随着年龄的增长而下降，而α-1球蛋白和胆固醇则增加。
Abstract Pathology, microbiology, and selected serum chemistries were evaluated in 144 male Fischer rats from 4 to 33 mo of age. The rats were reared and maintained under barrier conditions, which successfully excluded the introduction of major infectious disease agents throughout the entire study, including Mycoplasma pulmonis. A wide variety of pathology was found and tabulated, and many lesions were found to increase in severity and incidence with age. There was a high correlation of renal disease severity with increasing age. Serum total protein and albumin decreased with age, while alpha-1 globulin and cholesterol increased.