Histologic Categorization of Fibrotic Cancer Stroma in the Primary Tumor Is an Independent Prognostic Index in Resectable Colorectal Liver Metastasis
Histologic Categorization of Fibrotic Cancer Stroma in the Primary Tumor Is an Independent Prognostic Index in Resectable Colorectal Liver Metastasis
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DOI：
10.1097/pas.0000000000000232
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发表时间：
2014-10-01
影响因子：
5.6
通讯作者：
Yamamoto, Junji
中科院分区：
文献类型：
--
作者：
Ueno, Hideki;Konishi, Tsuyoshi;Yamamoto, Junji
Although the molecular mechanism of desmoplastic reaction (DR) for providing aggressive tumor characteristics is increasingly recognized, the prognostic role of DR has not been investigated in colorectal liver metastasis (CRLM). A pathologic review of 412 patients who underwent hepatectomy for CRLM at 2 independent institutions was conducted. DR in primary tumors was classified as mature, intermediate, or immature on the basis of the existence of keloid-like collagen and myxoid stroma-distinctive histologic products of extracellular matrix remodeling. With respect to DR, 137, 122, and 153 patients were classified as mature, intermediate, and immature, respectively. Immature DRs were associated with higher T and N stages, higher primary tumor grade, synchronous and larger size of liver metastasis, and extrahepatic disease (P
