Fabrication of a hollow mesoporous silica hybrid to improve the targeting of a pesticide
Fabrication of a hollow mesoporous silica hybrid to improve the targeting of a pesticide
复制标题
制备中空介孔二氧化硅杂化物以提高农药的靶向性
DOI：
10.1016/j.cej.2019.01.105
复制
发表时间：
2019-05-15
影响因子：
15.1
通讯作者：
Li, Jianhong
中科院分区：
文献类型：
--
作者：
Gao, Yunhao;Zhang, Yanhui;Li, Jianhong
纳米材料提供了一个很好的机会，开发新的策略，设计刺激响应控制释放配方（CRF）的农药。本研究制备了一种pH敏感的控制释放体系--聚甲基丙烯酸缩水甘油酯-丙烯酸共聚物（P（GMA-AA））接枝中空介孔二氧化硅（HMS@P（GMA-AA））。使用硬模板制造HMS并用甲基丙烯酸3-（三甲氧基甲硅烷基）丙酯官能化。然后采用种子沉淀聚合法将P（GMA-AA）接枝到HMS上。选择阿维菌素（阿坝）作为模型农药来测试其pH敏感性。详细的研究表明，阿坝@HMS@P（GMA-AA）表现出高的农药负载效率（33wt%）和优异的上级稳定性。阿坝从阿坝@HMS@P（GMA-AA）中的释放具有pH依赖性。此外，阿坝@HMS@P（GMA-AA）与水稻叶片结合力较强，主要得益于其对叶片的低接触角和高粘附功。室内和田间生物活性测定结果表明，阿坝@HMS@P（GMA-AA）对水稻稻纵卷叶螟幼虫的毒力高于阿坝乳油（Aba-EC），且具有长期药效。阿坝@HMS@P（GMA-AA）处理对水稻幼苗生长无明显影响。结果表明，所提出的控制释放系统是一个有前途的候选人的害虫管理。
Nanomaterials offer a great opportunity to develop new strategies for designing stimuli-responsive controlled release formulations (CRFs) of pesticides. In this study, a pH sensitive controlled release system, poly(glycidyl methacrylate-co-acrylic acid) (P(GMA-AA)) grafted hollow mesoporous silica (HMS@P(GMA-AA) was fabricated. HMS was fabricated using a hard template and functionalized with 3-(trimethoxysilyl)propyl methacrylate. Then, P(GMA-AA) was grafted onto HMS by seeded precipitation polymerization. Abamectin (aba) was selected as the model pesticide to test the pH-sensitivity property. Detailed investigations showed that Aba@HMS@P(GMA-AA) exhibited a high pesticide-loading efficiency (33 wt%) and superior stability. The release of Aba from Aba@HMS@P(GMA-AA) was pH-dependent. In addition, Aba@HMS@P(GMA-AA) showed a strong combination with rice leaves, mainly benefitting from its low contact angle and high adhesion work on leaves. Bioactivity studies in a greenhouse and the field indicated that Aba@HMS@P(GMA-AA) was more toxic than Aba emulsifiable concentrate (Aba-EC) in controlling rice pest Cnaphalocrocis medinalis (Guenee) larvae, and it possessed long-term efficacy in practice. Importantly, there was no obvious influence on the growth of rice seedlings treated with Aba@HMS@P(GMA-AA). The results suggest that the proposed controlled release system is a promising candidate for the management of pests.