ANTIBODIES IN HUMAN-SERA TO F(AB')2 FRAGMENTS OF MONOCLONAL AND POLYCLONAL IGG
ANTIBODIES IN HUMAN-SERA TO F(AB')2 FRAGMENTS OF MONOCLONAL AND POLYCLONAL IGG
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DOI：
10.1159/000232854
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发表时间：
1981-01-01
期刊：
影响因子：
--
通讯作者：
DRYSDALE, P
中科院分区：
文献类型：
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作者：
LING, NR;DRYSDALE, P
将人、牛和兔多克隆IgG和不同亚类和轻链类型的人IgG副蛋白的F（ab“）2片段偶联至人红细胞，并用于检测正常和病理性人血清中的凝集剂抗体。这种抗体在人血清中的常见性及其特异性的异质性得到证实。在单克隆B细胞增殖中未发现滴度或特异性变化。血清凝集素的可能意义进行了讨论。
F(ab'')2 fragments of human, bovine and rabbit polyclonal IgG and of human IgG paraproteins of different subclass and light-chain type were coupled to human red cells and used to detect agglutinator antibodies in normal and pathological human sera. The common occurrence of such antibodies in human sera and their heterogeneity in terms of specificity were confirmed. No change in titer or specificity was found in monoclonal B cell proliferations. The possible significance of serum agglutinators is discussed.