Treatment factors associated with long-term survival after cytoreductive surgery and regional chemotherapy for patients with malignant peritoneal mesothelioma
Treatment factors associated with long-term survival after cytoreductive surgery and regional chemotherapy for patients with malignant peritoneal mesothelioma
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DOI：
10.1016/j.surg.2013.01.001
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发表时间：
2013-06-01
期刊：
影响因子：
3.8
通讯作者：
Zhu, Yue
中科院分区：
文献类型：
--
作者：
Alexander, H. Richard, Jr.;Bartlett, David L.;Zhu, Yue
目标。恶性腹膜间皮瘤是一种弥漫性起源于腹膜内间皮细胞的原发肿瘤。发病率和死亡率几乎总是由局部区域进展引起的。细胞减少术(CRS)加术中或围手术期大剂量区域化疗已被确定为选定患者的首选方法。本研究旨在找出与长期结果相关的因素。对1992年1月至2010年1月在3个主要转诊中心接受手术CRS和术中高温腹膜化疗(HIPEC)治疗的211例MPM患者进行分析。中位、精算总生存率为38.4个月；精算5年和10年生存率分别为41%和26%。在多变量分析中，与预后相关的独立因素是较年轻的年龄。
Objectives. Malignant peritoneal mesothelioma (MF'M) is a primary cancer that arises diffusely from the mesothelial cells lining the peritoneum. Morbidity and mortality are almost invariably owing to locoregional progression. Cytoreduction surgery (CRS) with intraoperative or perioperative high-dose regional chemotherapy has been established as the preferred approach in selected patients. This study was performed to identify factors associated with long-term outcome.Methods. Between January 1992 and 2010, 211 patients with MPM treated at 3 major referral centers with operative CRS and hyperthermic intraoperative peritoneal chemotherapy (HIPEC) were analyzed.Results. The median, actuarial overall survival was 38.4 months; the actuarial 5- and 10-year survivals were 41% and 26%, respectively. On multivariate analysis, factors independently associated withjavorable outcome were younger age