A low interleukin-10 tumor necrosis factor-α ratio is associated with malaria anemia in children residing in a holoendemic malaria region in western Kenya
A low interleukin-10 tumor necrosis factor-α ratio is associated with malaria anemia in children residing in a holoendemic malaria region in western Kenya
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DOI：
10.1086/314548
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发表时间：
1999-01-01
影响因子：
6.4
通讯作者：
Udhayakumar, V
中科院分区：
文献类型：
--
作者：
Othoro, C;Lal, AA;Udhayakumar, V
Th 1型细胞因子（肿瘤坏死因子[TNF]-α、干扰素[IFN]-γ）和Th 2型细胞因子（白细胞介素[IL]-10、-4）之间的平衡可能在严重恶性疟疾的发展中至关重要。因此，这些细胞因子的血浆浓度测定在儿童与疟疾的各种表现。大多数儿童的血浆IFN-gamma和IL-4水平无法检测到。然而，与对照组儿童相比，高密度寄生虫血症和疟疾贫血儿童的TNF-α和IL-10显著升高。在轻度疟疾儿童中，IL-10而不是TNF-α显著升高。虽然在患有疟疾贫血的儿童中发现了最高浓度的TNF-α，但在患有高密度无并发症疟疾的儿童中IL-10水平最高。轻度和高密度寄生虫血症患儿IL-10/TNF-α的平均比值（4.64，P <0.005）显著高于疟疾贫血患儿（1.77）。因此，IL-10水平高于TNF-α水平可能通过控制TNF-α的过度炎症活动来预防疟疾贫血的发生。
The balance between Th1 cytokines (tumor necrosis factor [TNF]-alpha, interferon [IFN]-gamma) and Th2 cytokines (interleukin [IL]-10, -4) may be critical in the development of severe falciparum malaria. Therefore, plasma concentrations of these cytokines were determined in children with various manifestations of malaria. Plasma levels of IFN-gamma and IL-4 were undetectable in most children. However, TNF-alpha and IL-10 were significantly elevated in children with high-density parasitemia and malaria anemia compared with children in control groups. In children with mild malaria, IL-10, but not TNF-alpha, was significantly elevated. While the highest concentrations of TNF-alpha were found in children with malaria anemia, IL-10 levels were highest in children with high-density uncomplicated malaria. The mean ratio of IL-10 to TNF-alpha was significantly higher in children with mild and high-density parasitemia (4.64, P < .005) than in children with malaria anemia (1.77), Thus, higher levels of IL-10 over TNF-alpha may prevent development of malaria anemia by controlling the excessive inflammatory activities of TNF-alpha.