Non-Keratinizing Nasopharyngeal Carcinoma with Adenomatous Differentiation
Non-Keratinizing Nasopharyngeal Carcinoma with Adenomatous Differentiation
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伴有腺瘤分化的非角化性鼻咽癌
DOI：
10.1007/s12105-018-0991-6
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发表时间：
2018
影响因子：
2.1
通讯作者：
F. Petersson
中科院分区：
文献类型：
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作者：
F. Petersson
介绍了一例具有腺瘤分化的非角化性 EBV 阳性（EBER 原位杂交）癌。该患者是一名 40 岁男性，患有 T2N2M0 疾病，接受了标准化疗和放疗联合治疗，所有肿瘤均完全消退。肿瘤细胞低分子量细胞角蛋白（AE1-3）强阳性，分散细胞表达细胞角蛋白20。未检测到细胞角蛋白5/6、7、p63、TTF-1、CDX2或雄激素受体的表达。 19 个月后的随访（包括治疗后 MRI 和 PET-CT 扫描）没有证据表明复发或疾病进展。
A case of non-keratinizing, EBV-positive (EBER-in situ hybridization), carcinoma with adenomatous differentiation is presented. The patient is a 40 year old male with T2N2M0 disease who received standard combined chemo- and radiotherapy with complete resolution of all tumor. The tumor cells were strongly positive for low-molecular weight cytokeratins (AE1–3) and scattered cells expressed cytokeratin 20. No expression of cytokeratin 5/6, 7, p63, TTF-1, CDX2 or androgen receptor was detected. There was no evidence of recurrence or disease progression on follow-up after 19 months, which included post treatment MRI and PET–CT scans.