Collectins, collectin receptors and the lectin pathway of complement activation
Collectins, collectin receptors and the lectin pathway of complement activation
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DOI：
10.1111/j.1365-2249.1994.tb06254.x
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发表时间：
1994-08
影响因子：
4.6
通讯作者：
R. Malhotra;J. Lu;U. Holmskov;Robert B Sim
中科院分区：
文献类型：
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作者：
R. Malhotra;J. Lu;U. Holmskov;Robert B Sim
胶原凝集素是一组可溶性多聚体凝集素，其含有胶原片段，并且在其结构和功能方面类似于补体蛋白Clq。这组蛋白质，包括MBP，SP-A，SP-D，连接蛋白和CL-43，已知在各种情况下充当调理素，并且可能在先天免疫中发挥作用。目前研究的重点是追求这样的假设，即聚集素识别并结合微生物和颗粒上的非宿主碳水化合物结构，并参与Les Diahlerets，Switzerland，9-12 September 1994 5处理或消除此类材料，通过与吞噬细胞受体直接相互作用，或通过间接途径如补体激活。
The collectins are a group of soluble multimeric lectins, which contain collagenous segments, and resemble the complement protein Clq in aspects of their structures and functions. This group of proteins, which includes MBP, SP‐A, SP‐D, conglutinin and CL‐43, are known to act as opsonins in various circumstances, and are likely to have roles in innate immunity. The focus of current research is to pursue the hypothesis that the collectins recognize and bind to non‐host carbohydrate structures on microorganisms and particles, and participate in the Les Diahlerets, Switzerland, 9–12 September 1994 5 processing or elimination of such material, either by direct interaction with phagocytic cell receptors, or by indirect routes such as complement activation.