Cigarette smoking decreases tissue oxygen.
Cigarette smoking decreases tissue oxygen.
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DOI：
10.1001/archsurg.1991.01410330093013
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发表时间：
1991-09
影响因子：
--
通讯作者：
Jensen Ja;W. Goodson;H. Hopf;T. K. Hunt
中科院分区：
文献类型：
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作者：
Jensen Ja;W. Goodson;H. Hopf;T. K. Hunt
8名志愿者的皮下伤口组织氧分压（PsqO2）在吸烟后迅速显著下降，并在30至50分钟内保持较低水平。假“吸烟”没有任何影响。这些数据表明，一个典型的“每天一包”吸烟者在每天的大部分时间里都会经历组织缺氧。在动物和人体研究中，这些受试者中发现的缺氧程度与伤口愈合不良相关。组织缺氧的发生和持续时间破坏了尼古丁的公认血浆药代动力学。这表明尼古丁的肾上腺素能效应诱导的外周血管收缩可能导致观察到的PsqO2降低。
Subcutaneous wound-tissue oxygen (PsqO2) tension in eight volunteers fell rapidly and significantly in response to smoking, and remained low for 30 to 50 minutes. Sham "smoking" had no effect. These data suggest that a typical "pack-per-day" smoker experiences tissue hypoxia during a significant portion of each day. The degree of hypoxia found in these subjects has been associated with poor wound healing in animal and human studies. The onset and duration of tissue hypoxia paralleled the well-established plasma pharmacokinetics of nicotine. This suggests that peripheral vasoconstriction, induced by the adrenergic effects of nicotine, may contribute to the observed decrease in PsqO2.