Assessment of tumor morphology on diffusion-weighted (DWI) breast MRI: Diagnostic value of reduced field of view DWI.
Assessment of tumor morphology on diffusion-weighted (DWI) breast MRI: Diagnostic value of reduced field of view DWI.
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DOI：
10.1002/jmri.24929
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发表时间：
2015-12
期刊：
影响因子：
--
通讯作者：
Daniel BL
中科院分区：
文献类型：
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作者：
Barentsz MW;Taviani V;Chang JM;Ikeda DM;Miyake KK;Banerjee S;van den Bosch MA;Hargreaves BA;Daniel BL
比较常规、双侧弥散加权成像(DWI)和高分辨率靶向弥散加权成像(DWI)对已知乳腺病变的诊断价值。对21例确诊为乳腺癌或可疑乳腺病变的患者行常规双侧DWI、高分辨率缩小视野(RFOV)DWI和动态增强MRI(3.0T)扫描。通过测量病灶的ADC值，对双侧DWI和rFOV DWI进行定量比较。为了进行定性比较，三位专职的乳房放射科医生对图像质量进行了评分，并进行了病变解释。在体模中，ADC值与参考值吻合良好。21例患者共30个病灶，其中浸润性癌14个，良性病变10个(其中5个为囊性病变)，高危3个，原位癌3个。定量分析中排除了囊性病变和高危病变。在定量方面，双侧和rFOV弥散加权成像测量的侵袭性肿瘤的ADC值均低于其他病变。在体内，rFOVDWI的ADC值低于双侧DWI(1.11×10−3 mm~2/S vs 1.24×10−3 mm~2/S，P=0.002)。两种技术的感兴趣区大小相当(2.9 cm~2比2.13 cm~2，P=0.721)。定性上，三位放射科医生对rFOVDWI图像的清晰度评分均显著高于双侧弥散加权图像(P≤0.002)。ROC曲线分析显示，rFOV DWI的BI-RADS分类的AUC高于双侧DWI(分别为0.71~0.93和0.61~0.76)。通过提供明显更清晰的图像，高分辨率DWI(RFOV)可以比标准的双侧DWI更详细地评估肿瘤的形态。
To compare the diagnostic value of conventional, bilateral diffusion-weighted imaging (DWI) and high-resolution targeted DWI of known breast lesions. Twenty-one consecutive patients with known breast cancer or suspicious breast lesions were scanned with the conventional bilateral DWI technique, a high-resolution, reduced field of view (rFOV) DWI technique and dynamic contrast enhanced MRI (3.0 T). We compared bilateral DWI and rFOV DWI quantitatively by measuring the lesions’ ADC values. For qualitative comparison, three dedicated breast radiologists scored image quality and performed lesion interpretation. In a phantom, ADC values were in good agreement with the reference values. Twenty-one patients (30 lesions: 14 invasive carcinomas, 10 benign lesions (of which 5 cysts), 3 high risk and 3 in situ carcinomas) were included. Cysts and high-risk lesions were excluded from the quantitative analysis. Quantitatively, both bilateral and rFOV DWI measured lower ADC values in invasive tumors than other lesions. In vivo, rFOV DWI gave lower ADC values than bilateral DWI (1.11× 10−3 mm2/s vs. 1.24 × 10−3 mm2/s, P=0.002). ROIs were comparable in size between the two techniques (2.90 vs. 2.13 cm2, P=0.721). Qualitatively, all three radiologists scored sharpness of rFOV DWI images as significantly higher than bilateral DWI (P ≤ 0.002). ROC curve analysis showed a higher AUC in BI-RADS classification for rFOV DWI compared to bilateral DWI (0.71 to 0.93 vs. 0.61 to 0.76, respectively). Tumor morphology can be assessed in more detail with high-resolution DWI (rFOV) than with standard bilateral DWI by providing significantly sharper images.