Morphologic Observation of Mucosa‐Associated Lymphoid Tissue in the Large Intestine of Bactrian Camels (Camelus bactrianus)
Morphologic Observation of Mucosa‐Associated Lymphoid Tissue in the Large Intestine of Bactrian Camels (Camelus bactrianus)
复制标题
DOI：
10.1002/ar.22939
复制
发表时间：
2014-07
期刊：
影响因子：
--
通讯作者：
Y. Zhaxi;Wen-Hui Wang;Wang-dong Zhang;Q. Gao;Minggang Guo;Shuai Jia
中科院分区：
文献类型：
--
作者：
Y. Zhaxi;Wen-Hui Wang;Wang-dong Zhang;Q. Gao;Minggang Guo;Shuai Jia
采用解剖学和组织学方法对10只双峰驼大肠粘膜相关淋巴组织（MALT）的结构和分布进行了比较研究。结果显示，派尔氏淋巴结（PPs）主要位于整个回盲部口、盲肠起点和结肠前三分之一的粘膜表面。 PP的形状沿着大肠逐渐从“阴囊状”向“蚕状”转变，其中回盲部口以阴囊状PP为主。从回盲部口到结肠分布密度也逐渐降低。组织学观察进一步表明，MALT以PP或孤立淋巴滤泡（ILF）和固有层淋巴细胞的形式主要存在于从整个回盲部口（粘膜肌层通常不完整）到结肠前部的固有层和粘膜下层。此外，与盲肠和结肠相比，回盲部固有层和粘膜下层的淋巴组织更加丰富。据统计，回盲部口的MALT含有比盲肠、结肠或直肠更多的淋巴滤泡（37.7/10 mm2）（P < 0.05）。淋巴滤泡的生发中心清晰可见。总之，我们的数据表明，回盲孔口构成了双峰驼大肠粘膜免疫的主要诱导位点；阴囊状PP很可能是双峰驼长期适应恶劣生活环境的结果。 Anat Rec，297:1292–1301，2014。© 2014 Wiley periodicals, Inc.
The structure and distribution of the mucosa‐associated lymphoid tissue (MALT) throughout the large intestine of 10 Bactrian camels were comparatively studied by anatomical and histological methods. The results showed that Peyer's patches (PPs) were mainly located on the mucosal surfaces of the entire ileocecal orifice, the beginning of the cecum and the first third of the colon. The shape of PPs gradually changed from “scrotiform” to “faviform” along the large intestine with the scrotiform PP as the major type in the ileocecal orifice. The distribution density also gradually decreased from the ileocecal orifice to the colon. The histological observations further revealed that the MALT in the form of PPs or isolated lymphoid follicles (ILF) and lamina propria lymphocytes was mainly present in the lamina propria and submucosa from the entire ileocecal orifice, where the muscularis mucosa is usually incomplete, to the colonic forepart. In addition, lymphoid tissue was much more abundant in the lamina propria and submucosa of the ileocecal orifice as compared to the cecum and colon. Statistically, the MALT of the ileocecal orifice contained a higher number of lymphoid follicles (37.7/10 mm2) than that of the cecum, colon, or rectum (P < 0.05). The germinal centers of the lymphoid follicles were clearly visible. Together, our data suggest that the ileocecal orifice constitutes the main inductive site for the mucosal immunity in the large intestine of the Bactrian camel; and that scrotiform PPs are likely to the result of long‐term adaptation of the Bactrian camel to the harsh living environment. Anat Rec, 297:1292–1301, 2014. © 2014 Wiley Periodicals, Inc.