One-pot synthesis of hydrophilic ZnCuInS/ZnS quantum dots for in vivo imaging
One-pot synthesis of hydrophilic ZnCuInS/ZnS quantum dots for in vivo imaging
复制标题
一锅合成用于体内成像的亲水性 ZnCuInS/ZnS 量子点
DOI：
10.1039/c3ra40752g
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发表时间：
2013-01-01
期刊：
影响因子：
3.9
通讯作者：
Zhang, Bingbo
中科院分区：
文献类型：
--
作者：
Guo, Weisheng;Chen, Na;Zhang, Bingbo
在有机相中合成CuInS基量子点是目前纳米技术发展最快的一个研究热点。大多数报道的基于CuInS的量子点是疏水的，并且不能在没有相转移的情况下直接用于生物医学应用。我们提出了一种一锅法合成Zn-Cu-In-S/ZnS（ZCIS/ZnS）量子点的方法，该量子点无需表面处理即可直接用于体内成像。该策略基于亲水性配体（6-硫烷基-1-己醇，MPH）和非配位溶剂如低分子量聚乙二醇（PEG，MW = 400 Da）的使用。封端配体MPH赋予所获得的ZCIS/ZnS量子点具有良好的亲水性，因此为无相转移的直接生物成像应用提供了很大的机会。实验结果表明，这些所谓的亲水性ZCIS/ZnS量子点显示出低细胞毒性，并成功地用于体内成像。此外，这里报道的策略不仅提出了一个合成的想法，但也可能激发其他创新的想法，制造亲水性或水溶性的ZCIS/ZnS量子点，直接用于生物应用。
Synthesis of CuInS-based quantum dots (QDs) in the organic phase is currently one of the fastest growing points of nanotechnology. Most of the reported CuInS-based QDs are hydrophobic and cannot be directly used for biomedical applications without phase transfer. We put forward a one-pot synthetic strategy aimed at fabricating hydrophilic Zn–Cu–In–S/ZnS (ZCIS/ZnS) quantum dots (QDs) to be used directly for in vivo imaging without surface treatment. This strategy is based on the use of a hydrophilic ligand (6-sulfanyl-1-hexanol, MPH) and non-coordinating solvents such as a low molecular weight polyethylene glycol (PEG, MW = 400 Da). The capping ligand MPH endows the obtained ZCIS/ZnS QDs with good hydrophilicity and therefore offers great opportunity for direct bioimaging applications without phase transfer. Experimental results have indicated that these so-called hydrophilic ZCIS/ZnS QDs show low cytotoxicity and are successfully utilized for in vivo imaging. Furthermore, the here reported strategy doesn't only present a synthetic idea, but also might stimulate other innovative ideas on fabricating hydrophilic or water-soluble ZCIS/ZnS QDs to be used directly for biological applications.