Blood-Borne Activity-Dependent Neuroprotective Protein (ADNP) is Correlated with Premorbid Intelligence, Clinical Stage, and Alzheimer's Disease Biomarkers.
Blood-Borne Activity-Dependent Neuroprotective Protein (ADNP) is Correlated with Premorbid Intelligence, Clinical Stage, and Alzheimer's Disease Biomarkers.
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DOI：
10.3233/jad-150799
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Gozes I
中科院分区：
文献类型：
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作者：
Malishkevich A;Marshall GA;Schultz AP;Sperling RA;Aharon-Peretz J;Gozes I
阿尔茨海默病(AD)的生物标志物对于临床环境中的疾病检测至关重要。我们实验室发现，活性依赖神经保护蛋白(ADNP)是大脑形成所必需的，与认知功能有关。在此，我们揭示了ADNP及其同源基因ADNP2在血液中的表达与发病前智力、AD病理和临床分期相关。年龄调整显示：1)较高的病前智商和较高的血清ADNP，以及2)较大的皮质淀粉样蛋白和较低的ADNP和ADNP2 mRNAs。在从轻度认知障碍(MCI)到AD痴呆的患者中，ADNP mRNA水平显著升高。ADNP2转录本与ADNP转录本高度相关，尤其是在AD痴呆淋巴细胞中。ADNP血浆/血清和淋巴细胞mRNA水平在认知正常的老年人、MCI和AD痴呆参与者之间有很好的区分。测量ADNP的血液传播水平可以使我们离有效筛查和跟踪AD更近一步。
Biomarkers for Alzheimer’s disease (AD) are vital for disease detection in the clinical setting. Discovered in our laboratory, activity-dependent neuroprotective protein (ADNP) is essential for brain formation and linked to cognitive functions. Here, we revealed that blood borne expression of ADNP and its paralog ADNP2 is correlated with premorbid intelligence, AD pathology, and clinical stage. Age adjustment showed significant associations between: 1] higher premorbid intelligence and greater serum ADNP, and 2] greater cortical amyloid and lower ADNP and ADNP2 mRNAs. Significant increases in ADNP mRNA levels were observed in patients ranging from mild cognitive impairment (MCI) to AD dementia. ADNP2 transcripts showed high correlation with ADNP transcripts, especially in AD dementia lymphocytes. ADNP plasma/serum and lymphocyte mRNA levels discriminated well between cognitively normal elderly, MCI, and AD dementia participants. Measuring ADNP blood-borne levels could bring us a step closer to effectively screening and tracking AD.