Novel Perspectives for the Treatment of Gastric Cancer: From a Global Approach to a Personalized Strategy
Novel Perspectives for the Treatment of Gastric Cancer: From a Global Approach to a Personalized Strategy
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DOI：
10.1007/s11912-010-0101-8
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发表时间：
2010-05-01
影响因子：
4.7
通讯作者：
Cascinu, Stefano
中科院分区：
文献类型：
--
作者：
Scartozzi, Mario;Pistelli, Mirco;Cascinu, Stefano
尽管最近取得了进展，但手术仍然是胃癌患者任何根治性治疗的主要手段，根治性胃切除术是首选的手术方式。然而，局部晚期疾病的患者即使在潜在的根治性切除后，也显示出较高的局部或远处复发率。根据局部进展期可切除胃癌的全球研究结果，围手术期化疗可能被认为是一个有价值的选择。另一方面，进展期胃癌的临床试验似乎表明，标准化疗的疗效已经达到了极限。与其他癌症部位类似，靶向药物的开发也显示了令人感兴趣的胃癌结果，预计会有有趣的数据出现。除了新的有效治疗机会，更好的临床和分子驱动的患者选择将是这些患者全球护理的基石。
Although recent advances have been made, surgery still remains the mainstay of any curative treatment for gastric cancer patients, with radical gastrectomy representing the procedure of choice. However, patients with locally advanced disease show high rates of locoregional or distant recurrence even after potentially curative resections. According to global results presented in the setting of locally advanced resectable gastric carcinoma, perioperative chemotherapy may be considered a valuable option. On the other hand, clinical trials for advanced gastric cancer seem to suggest that a limit in efficacy has been reached for standard chemotherapy. Interesting data are expected from the development of targeted agents that, similarly to other cancer sites, showed appealing results in gastric cancer as well. Along with new effective therapeutic opportunities, better clinical and molecularly driven patient selection will represent the cornerstone of the global care for these patients.