Reflex tracheal gland secretion evoked by stimulation of bronchial C-fibers in dogs.
Reflex tracheal gland secretion evoked by stimulation of bronchial C-fibers in dogs.
复制标题
刺激狗支气管 C 纤维引起反射性气管腺分泌。
DOI：
10.1152/jappl.1982.53.4.985
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Coleridge,JC
中科院分区：
文献类型：
--
作者：
Davis,B;Roberts,AM;Coleridge,HM;Coleridge,JC
本文研究了经下气管通气、开胸麻醉犬刺激支气管c纤维对其气管粘膜下腺分泌的影响。我们在中线处打开上气管，收缩切口，将粉末状钽喷在暴露的粘膜上。粘膜下腺导管的分泌物引起钽层升高（丘），通过显微镜观察并用电视摄像机记录在录像带上。在支气管动脉注射辣椒素（3微克）刺激支气管c -纤维前后，我们统计了粘膜区域（1.2 cm2）的丘（直径大于0.2 mm）。注射辣椒素前1分钟出现7 +/- 2个（平均+/- SE， n = 20）丘，注射辣椒素后1分钟出现40 +/- 2个丘。缓激素（1.5微克）也有类似的效果。分泌时伴有气管肌收缩。通过冷却（0℃）或切断迷走神经来消除效果。由于辣椒素和缓激素在小剂量注射时选择性刺激支气管c纤维，我们得出结论，支气管c纤维提供气道分泌反射的传入臂。
We examined the effect of stimulating bronchial C-fibers on tracheal submucosal gland secretion in anesthetized dogs with open chest and lungs ventilated through the lower trachea. We opened the upper trachea in the midline, retracted the cut edges, and sprayed powdered tantalum onto the exposed mucosa. Secretions from the ducts of submucosal glands caused elevations (hillocks) in the tantalum layer, which were viewed through a microscope and recorded on videotape with a television camera. We counted the hillocks (greater than 0.2 mm diam) in an area of mucosa (1.2 cm2) before and after injecting capsaicin (3 micrograms) into a bronchial artery to stimulate bronchial C-fibers. In the minute before capsaicin was injected 7 +/- 2 (mean +/- SE; n = 20) hillocks appeared and in the minute after 40 +/- 2 hillocks. Bradykinin (1.5 micrograms) had similar effects. Secretion was accompanied by contraction of the trachealis muscle. Effects were abolished by cooling (0 degree C) or cutting the vagus nerves. Since capsaicin and bradykinin stimulate bronchial C-fibers selectively when injected in these small doses, we conclude that bronchial C-fibers furnish the afferent arm of an airway secretory reflex.