Types of Cholecystokinin-Containing Periglomerular Cells in the Mouse Olfactory Bulb
Types of Cholecystokinin-Containing Periglomerular Cells in the Mouse Olfactory Bulb
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DOI：
10.1002/jnr.22521
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发表时间：
2011-01-01
影响因子：
4.2
通讯作者：
Weruaga, Eduardo
中科院分区：
文献类型：
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作者：
Baltanas, Fernando C.;Curto, Gloria G.;Weruaga, Eduardo
嗅球球周围细胞（perigglomerular cells，PG）参与嗅上皮对感觉信息的初级加工和精细化。这些神经元的神经化学成分已经在许多物种中进行了深入的研究，在过去的几十年中，这些研究主要集中在大鼠身上。越来越多地使用遗传模型研究嗅觉功能，需要一个深刻的表征小鼠嗅球，包括球中间神经元的化学组成。关于它们与嗅觉神经的连接和它们的神经化学命运，最近，在小鼠中已经鉴定出两种不同类型的PG。在本报告中，我们分析了突触学和化学组成的特定PG种群在小鼠嗅球，特别是那些含有神经肽胆囊收缩素。我们的研究结果表明，在小鼠中存在的非GABA能PG，这些建立与嗅神经内的肾小球突触联系。根据以前的分类，我们建议，这个人口将构成一个新的亚型1型小鼠PG。此外，我们证明了部分共存的胆囊收缩素与钙结合蛋白神经钙蛋白和小清蛋白。所有这些研究结果增加了进一步的数据，我们的知识的突触学和神经化学的小鼠PG。从其他啮齿类动物中观察到的差异反映了PG在哺乳动物OB的神经化学异质性。(C)2010 Wiley-Liss，Inc.
The periglomerular cells (PG) of the olfactory bulb (OB) are involved in the primary processing and the refinement of sensory information from the olfactory epithelium. The neurochemical composition of these neurons has been studied in depth in many species, and over the last decades such studies have focused mainly on the rat. The increasing use of genetic models for research into olfactory function demands a profound characterization of the mouse olfactory bulb, including the chemical composition of bulbar interneurons. Regarding both their connectivity with the olfactory nerve and their neurochemical fate, recently, two different types of PG have been identfied in the mouse. In the present report, we analyze both the synaptology and the chemical composition of specific PG populations in the murine olfactory bulb, in particular, those containing the neuropeptide cholecystokinin. Our results demonstrate the existence in the mouse of non-GABAergic PG and that these establish synaptic contacts with the olfactory nerve within the glomeruli. Based on previous classifications, we propose that this population would constitute a new subtype of type 1 mouse PG. In addition, we demonstrate the partial coexistence of cholecystokinin with the calcium-binding proteins neurocalcin and parvalbumin. All these findings add further data to our knowledge of the synaptology and neurochemistry of mouse PG. The differences observed from other rodents reflect the neurochemical heterogeneity of PG in the mammalian OB. (C) 2010 Wiley-Liss, Inc.