Identification of new medium reiteration frequency repeats in the genomes of Primates, Rodentia and Lagomorpha
Identification of new medium reiteration frequency repeats in the genomes of Primates, Rodentia and Lagomorpha
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DOI：
10.1007/bf00057588
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发表时间：
1996-01-01
期刊：
影响因子：
1.5
通讯作者：
Smit, AFA
中科院分区：
文献类型：
--
作者：
Jurka, J;Kapitonov, VV;Smit, AFA
我们报道了在灵长类、啮齿目和兔形目动物基因组中分布着11个新的中等重复频率(Mer)重复序列。人类重复序列的两个家族MER46和MER47代表非自主的DNA转座子。这些序列的两侧是TA靶点重复序列，其末端反向重复序列(TIR)类似于DNA的TIR。转座子。另外五个重复序列家族MER41、MER48、MER50、MER51和RMER3的序列与逆转录病毒的长末端重复序列相似。一些已报道的Mer重复序列可能参与了转录和基因重排的调节。年龄估计将大多数Mer重复序列的起源放在MIR(哺乳动物范围的散布重复序列)回位下降的时候，并且在Alu家族起源之前。
We report eleven new families of MEdium Reiteration frequency (MER) interspersed repeats in the genomes of Primates, Rodentia, and Lagomorpha. Two families of the human repeats, MER46 and MER47, represent non-autonomous DNA transposons. These sequences are flanked by TA target site duplications and have terminal inverted repeats (TIRs) similar to TIRs of DNA. transposons. The sequences of five other families of repeats, MER41, MER48, MER50, MER51, and RMER3, resemble long terminal repeats of retroviruses. A potential involvement of some of the reported MER repeats in the regulation of transcription and genetic rearrangements is suggested. Age estimations place the origin of most MER repeats at the time of decline in MIR (Mammalian-wide Interspersed Repeats) retroposition and before the origin of the Alu family.