One-Pot Synthesis of Pyrrolo[3,2,1-kl]phenothiazines through Copper-Catalyzed Tandem Coupling/Double Cyclization Reaction.
One-Pot Synthesis of Pyrrolo[3,2,1-kl]phenothiazines through Copper-Catalyzed Tandem Coupling/Double Cyclization Reaction.
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DOI：
10.1021/acs.joc.5b01745
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发表时间：
2015-10
期刊：
影响因子：
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通讯作者：
Jiaming Tang;Bin Xu;Xi Mao;Hongyan Yang;Xiaoxia Wang;Xin Lv
中科院分区：
文献类型：
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作者：
Jiaming Tang;Bin Xu;Xi Mao;Hongyan Yang;Xiaoxia Wang;Xin Lv
采用Cu（I）催化的C-S偶联/双环合串联反应合成了吡咯并[3，2，1-kl]吩噻嗪类化合物。以2-炔基-6-碘苯胺和邻溴苯硫酚为原料，在铜（I）催化下，一锅法简便、高效地合成了多种吡咯并[3，2，1-kl]吩噻嗪衍生物。
A novel and efficient synthesis of pyrrolo[3,2,1-kl]phenothiazines has been developed through a Cu(I)-catalyzed tandem C-S coupling/double cyclization process. Using 2-alkynyl-6-iodoanilines and o-bromobenzenethiols as the starting materials, a wide range of pyrrolo[3,2,1-kl]phenothiazine derivatives were facilely and efficiently generated in one pot under Cu(I) catalysis.