Functional grouping of osteoclast genes revealed through microarray analysis.

Functional grouping of osteoclast genes revealed through microarray analysis.
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通过微阵列分析揭示破骨细胞基因的功能分组。

DOI:
10.1016/j.bbrc.2007.11.106
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发表时间:
2008
影响因子:
3.1
通讯作者:
Sun,Li
Sun,Li
中科院分区:
生物学4区
文献类型:
--
作者:
Yang,Guozhe;Zaidi,Mone;Zhang,Weijia;Zhu,Ling-Ling;Li,Jianhua;Iqbal,Jameel;Varbanov,Alex;Gross,Gary;Phipps,Roger;Troen,BruceR;Sun,Li

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We describe for the first time functional clusters of genes that are modulated during the differentiation of osteoclasts. Pathway analysis was applied to gene array data generated from affymetrix chips hybridized to RNA isolated from RAW264.7 cells exposed to RANK-ligand (RANK-L) for 5 days. This analysis revealed major functional gene clusters that were either up- or down-regulated during osteoclastogenesis. Some of the genes within the clusters have known functions, while others do not. We discuss herein the relevance of these functional gene clusters and their modulation to biological processes underlying the formation, function, and fate of osteoclasts.
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