Recurrent varicella zoster virus myelopathy.

Recurrent varicella zoster virus myelopathy.
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DOI:
10.1016/j.jns.2008.09.025
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发表时间:
2009-01-15
影响因子:
4.4
通讯作者:
Tanabe, Jody L.
Tanabe, Jody L.
中科院分区:
医学3区
文献类型:
--
作者:
Gilden, Don;Nagel, Maria A.;Ransohoff, Richard M.;Cohrs, Randall J.;Mahalingam, Ravi;Tanabe, Jody L.

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脊髓病是一种罕见的并发症VZV感染,并可能发展没有皮疹。我们报告一个免疫功能正常的成人,在眼部带状疱疹后,最初发展为脊髓病,罕见的脊髓病复发。两年后由VZV引起的复发性脊髓病通过存在与脊髓病一致的新发临床症状和体征、通过MRI检测到的脊髓中的新病变以及CSF中抗VZV IgG抗体的鞘内合成的证据来证实。经病毒学验证和抗病毒治疗后,脊髓病未复发,脑脊液中未检测到抗VZV IgG抗体。与免疫功能正常的成年人在首次脊髓病发作后数周至数月发生的复发性VZV脊髓病的早期病例相反,这是多年后复发的第一例。
Myelopathy is an uncommon complication of VZV infection and may develop in the absence of rash. We report the rare recurrence of myelopathy in an immunocompetent adult who initially developed myelopathy after ophthalmic-distribution zoster. Recurrent myelopathy two years later caused by VZV was verified by the presence of new- onset clinical symptoms and signs consistent with myelopathy, new lesions in the spinal cord detected by MRI, and evidence of intrathecal synthesis of anti-VZV IgG antibody in CSF. After virological verification and antiviral therapy, myelopathy did not recur and anti-VZV IgG antibody could not be detected in CSF. In contrast to earlier cases of recurrent VZV myelopathy in immunocompetent adults that developed weeks to months after the first episode of myelopathy, this is the first instance of recurrence years later.
DOI: 10.1159/000080270
发表时间: 2004-01-01
期刊: EUROPEAN NEUROLOGY
影响因子: 2.4
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