Antifungal cyclic depsipeptide, eujavanicin A, isolated from Eupenicillium javanicum
Antifungal cyclic depsipeptide, eujavanicin A, isolated from Eupenicillium javanicum
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DOI：
10.1021/np8002904
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发表时间：
2008-09-01
影响因子：
5.1
通讯作者：
Yaguchi, Takashi
中科院分区：
文献类型：
--
作者：
Nakadate, Shou;Nozawa, Koohei;Yaguchi, Takashi
在寻找新的抗真菌药物的过程中，从爪哇正青霉菌中分离到一种新的环状缩酚酸肽，euvanicin A（1），它对人类致病性丝状真菌烟曲霉具有抗真菌作用。化合物1的结构经光谱和化学研究确定。通过Marvelt方法和手性HPLC分析阐明了绝对立体化学。
In the course of searching for new antifungal agents, a new cyclic depsipeptide, eujavanicin A (1), wits isolated from Eupenicillium javanicum as an antifungal agent against the human pathogenic filamentous fungus Aspergillus fumigatus. The structure of 1 was established by spectroscopic and chemical investigations. The absolute stereochemistry was elucidated by Marfey's method and by chiral HPLC analysis.