Comparison of Retinal Nerve Fiber Layer Thickness Measurement Bias and Imprecision across Three Spectral-Domain Optical Coherence Tomography Devices
Comparison of Retinal Nerve Fiber Layer Thickness Measurement Bias and Imprecision across Three Spectral-Domain Optical Coherence Tomography Devices
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DOI：
10.1167/iovs.11-8432
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发表时间：
2012-06-01
影响因子：
4.4
通讯作者：
Schuman, Joel S.
中科院分区：
文献类型：
--
作者：
Buchser, Nancy M.;Wollstein, Gadi;Schuman, Joel S.
目的。我们比较了三种光谱域光学相干断层扫描（SD-OCT）的视网膜神经纤维层（RNFL）偏差和不精确性。83名受试者共152只眼（健康96只眼，青光眼56只眼）在同一天使用以下3种SD-OCT设备中的至少2种进行了乳头周围RNFL成像：Cirrus HD-OCT（视神经头[ONH]）立方体200 × 200方案)、RTVue-100 （ONH方案[12条径向线和13个同心圆]）和3D OCT-1000 （3D扫描256 × 256方案）。利用结构方程模型计算RNFL测量的校准方程、偏差和不精度。3种设备间健康和青光眼视网膜厚度测量的标定方程为：Cirrus = 2.136 + 0.831*RTVue；卷云= -15.521 + 1.056*3D OCT-1000；RTVue = -21.257 + 1.271*3D OCT-1000。使用Cirrus偏倚作为任意参考，RTVue偏倚增大1.20倍（95% CI 1.09-1.32, P < 0.05）， 3D OCT-1000偏倚减小0.95倍（0.87-1.03,P < 0.05）。相对于3D OCT-1000， RTVue偏倚为1.27 （1.13 ~ 1.42,P < 0.05）。RTVue不精度（健康眼7.83,95% CI 6.43 ~ 9.58；青光眼5.71,4.19 ~ 7.64）高于Cirrus（健康眼3.23,2.11 ~ 4.31；青光眼3.53,0.69 ~ 5.24）和3D OCT-1000（健康眼4.07,3.11 ~ 5.35；青光眼5.33,3.77 ~ 7.67）。与青光眼相比，健康眼RTVue测量的不精确性也明显更高。其他比较均无统计学意义。RTVue-100比卷云HD-OCT和3D OCT-1000 RNFL测量结果显示更高的不精度（或更高的测量变异性）。三维立方体扫描与事后数据采样可能是一个因素，以减少不精确。（Invest Ophthalmol Vis Sci. 2012;53:3742-3747） DOI:10.1167/iovs.11-8432
PURPOSE. We compared retinal nerve fiber layer (RNFL) bias and imprecision among three spectral-domain optical coherence tomographs (SD-OCT).METHODS. A total of 152 eyes of 83 subjects (96 healthy and 56 glaucomatous eyes) underwent peripapillary RNFL imaging using at least 2 of the following 3 SD-OCT devices on the same day: Cirrus HD-OCT (optic nerve head [ONH]) cube 200 x 200 protocol), RTVue-100 (ONH protocol [12 radial lines and 13 concentric circles]), and 3D OCT-1000 (3D Scan 256 x 256 protocol). Calibration equations, bias and imprecision of RNFL measurements were calculated using structural equation models.RESULTS. The calibration equations for healthy and glaucoma RNFL thickness measurements among the 3 devices were: Cirrus = 2.136 + 0.831*RTVue; Cirrus = -15.521 + 1.056*3D OCT-1000; RTVue = -21.257 + 1.271*3D OCT-1000. Using Cirrus bias as an arbitrary reference, RTVue bias was 1.20 (95% CI 1.09-1.32, P < 0.05) times larger and 3D OCT-1000 was 0.95 (0.87-1.03, P > 0.05) times smaller. Relative to 3D OCT-1000, the RTVue bias was 1.27 (1.13-1.42, P < 0.05). RTVue imprecision (healthy eyes 7.83, 95% CI 6.43-9.58; glaucoma cases 5.71, 4.19-7.64) was statistically significantly higher than both Cirrus (healthy eyes 3.23, 2.11-4.31; glaucoma cases 3.53, 0.69-5.24) and 3D OCT-1000 (healthy eyes 4.07, 3.11-5.35; glaucoma cases 5.33, 3.77-7.67) in healthy eyes. The imprecision also was significantly higher for RTVue measurements in healthy compared to glaucomatous eyes. None of the other comparisons was statistically significant.CONCLUSIONS. RTVue-100 showed higher imprecision (or higher measurement variability) than Cirrus HD-OCT and 3D OCT-1000 RNFL measurements. Three-dimensional cube scanning with post-hoc data sampling may be a factor reducing imprecision. (Invest Ophthalmol Vis Sci. 2012;53:3742-3747) DOI:10.1167/iovs.11-8432